Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 8/20 | 0.44 |
| ▸ | HTT | P42858 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | TMPRSS15 | P98073 | 2/20 | 0.43 |
| ▸ | RAD52 | P43351 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3752321 | 0.92 | SMN1; SMN2 (0.51) | SMN1; SMN2KEAP1MAPTHTTKMT2A | |
| Hydrochloric Acid SCHEMBL3753726 | 0.90 | SMN1; SMN2 (0.50) | SMN1; SMN2KEAP1MAPTHTTKMT2A | |
| SCHEMBL3748595 | 0.88 | LMNA (0.50) | SMN1; SMN2KEAP1MAPTHTTKMT2A | |
| Hydrochloric Acid SCHEMBL3746728 | 0.87 | CYP1A2 (0.51) | SMN1; SMN2KEAP1MAPTHTTKMT2A | |
| SCHEMBL3748709 | 0.83 | SMN1; SMN2 (0.41) | SMN1; SMN2KEAP1MAPTHTTKMT2A | |
| SCHEMBL23965817 | 0.82 | SMN1; SMN2 (0.48) | SMN1; SMN2KEAP1MAPTHTTKMT2A | |
| SCHEMBL3744447 | 0.82 | LMNA (0.52) | SMN1; SMN2KEAP1MAPTHTTKMT2A | |
| SCHEMBL19326467 | 0.80 | MAPT (0.51) | SMN1; SMN2KEAP1MAPTHTTKMT2A | |
| SCHEMBL18344029 | 0.80 | MAPT (0.45) | SMN1; SMN2MAPTHTTKMT2AALDH1A1 | |
| SCHEMBL3748799 | 0.79 | SMN1; SMN2 (0.44) | SMN1; SMN2KEAP1MAPTHTTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1828177-B1 | NOVEL MCH RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2008-08-13 | — | — | EP | disclosed |
| EP-1828177-A2 | NOVEL MCH RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2007-09-05 | — | — | EP | disclosed |
| WO-2006066173-A2 | NOVEL MCH RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2006-06-22 | — | — | WO | disclosed |