SCHEMBL4643684

SCHEMBL4643684

O=S(=O)([O-])C(F)(F)C(F)(F)C(F)(F)C(F)(F)F.O=S(=O)([O-])C(F)(F)C(F)(F)C(F)(F)C(F)(F)F.c1ccc([I+]c2ccc(Oc3ccc([S+](c4ccccc4)c4ccccc4)cc3)cc2)cc1

nearest known ligand 0.32

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
SOS1 Q07889 1/20 0.32
NR3C1 P04150 1/20 0.31
PGR P06401 1/20 0.31
AR P10275 1/20 0.31
ESR2 Q92731 1/20 0.31
HTT P42858 1/20 0.30
SMN1; SMN2 Q16637 1/20 0.30
LMNA P02545 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4643827 0.99 SOS1 (0.33) SOS1NR3C1PGRARESR2
SCHEMBL5439943 0.92 SOS1 (0.37) SOS1NR3C1PGRARESR2
SCHEMBL5432693 0.90 SOS1 (0.36) SOS1NR3C1PGRARESR2
SCHEMBL4647570 0.88 HTT (0.31) HTTSMN1; SMN2
SCHEMBL4643483 0.88 HTT (0.31) HTTSMN1; SMN2
SCHEMBL4641860 0.88 HTT (0.35) HTTSMN1; SMN2
SCHEMBL4643440 0.88 PTPN1 (0.33)
Trifluoromethanesulfonic Acid SCHEMBL6022880 0.88 SOS1 (0.36) SOS1NR3C1PGRARESR2
Trifluoromethanesulfonic Acid SCHEMBL4643549 0.86 SOS1 (0.37) SOS1NR3C1PGRARESR2
SCHEMBL4642255 0.86 CA1 (0.35)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1443042-B1 HYBRID ONIUM SALT WAKO PURE CHEM IND LTD (JP) 2008-08-13 EP disclosed
US-7101918-B2 Hybrid type onium salt WAKO PURE CHEMICAL INDUSTRIES, LTD. (JP) 2006-09-05 US disclosed
US-20050020710-A1 Hybrid onium salt WAKO PURE CHEMICALS INDUSTRIES, LTD. (JP) 2005-01-27 US disclosed
EP-1443042-A1 HYBRID ONIUM SALT Wako Pure Chemical Industries, Ltd. (JP) 2004-08-04 EP disclosed