Fluocortolone

Fluocortolone

SCHEMBL4644

C[C@@H]1C[C@H]2[C@@H]3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@H]3[C@@H](O)C[C@]2(C)[C@H]1C(=O)CO

nearest known ligand 0.70

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PGR P06401 9/20 0.70
AR P10275 6/20 0.70
ADRA1A P35348 2/20 0.70
CHRM1 P11229 2/20 0.70
ADORA3 P0DMS8 2/20 0.70
SLC6A2 P23975 1/20 0.70
SLC6A3 Q01959 1/20 0.70
KCNH2 Q12809 1/20 0.70
NR1I2 O75469 3/20 0.61
HTR2B P41595 1/20 0.61
CYP3A4 P08684 7/20 0.56
NR3C1 P04150 6/20 0.56
ABCB11 O95342 5/20 0.56
HSD17B10 Q99714 2/20 0.56
LMNA P02545 2/20 0.56
KDM4E B2RXH2 1/20 0.56
CYP2C19 P33261 1/20 0.56
HTR1A P08908 1/20 0.56
ADRA2A P08913 1/20 0.56
HIF1A Q16665 6/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Fluocortolone SCHEMBL21706397 1.00 PGR (0.70) PGRARADRA1ACHRM1ADORA3
Fluocortolone SCHEMBL11518086 1.00 PGR (0.70) PGRARADRA1ACHRM1ADORA3
Fluocortolone SCHEMBL11862489 1.00 PGR (0.70) PGRARADRA1ACHRM1ADORA3
Fluocortolone SCHEMBL19327147 1.00 PGR (0.70) PGRARADRA1ACHRM1ADORA3
Fluocortolone SCHEMBL3047399 1.00 PGR (0.70) PGRARADRA1ACHRM1ADORA3
Fluocortolone SCHEMBL13902941 1.00 PGR (0.70) PGRARADRA1ACHRM1ADORA3
Fluocortolone SCHEMBL11333890 1.00 PGR (0.70) PGRARADRA1ACHRM1ADORA3
Fluocortolone SCHEMBL144059 0.99 PGR (0.69) PGRARADRA1ACHRM1ADORA3
Fluocortolone SCHEMBL21852268 0.98 PGR (0.68) PGRARADRA1ACHRM1ADORA3
Fluocortolone SCHEMBL3690986 0.97 PGR (0.67) PGRARADRA1ACHRM1ADORA3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 16229 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260139030-A1 CHIMERIC PROTEINS FOR TREATING CUTANEOUS INFLAMMATION SHATTUCK LABS INC (US) 2026-05-21 US claimed
EP-4255391-B1 LUMINOL FOR USE IN THE TREATMENT OF SEQUELAE OF A SARS-COV-2 INFECTION METRIOPHARM AG (CH) 2026-05-06 EP claimed
US-20260108619-A1 CONJUGATION LINKERS, CELL BINDING MOLECULE-DRUG CONJUGATES CONTAINING THE LINKERS, METHODS OF MAKING AND USES SUCH CONJUGATES WITH THE LINKERS HANGZHOU DAC BIOTECH CO., LTD. (CN) 2026-04-23 US claimed
US-20260103492-A1 CYCLOSPORINE COMPOSITIONS AND METHODS OF USE BACAINN BIOTHERAPEUTICS, LTD. (KY) 2026-04-16 US claimed
EP-4724049-A1 MODIFIED RELEASE FILL COMPOSITIONS FOR DOSAGE FORMS AND METHODS OF PREPARATION AND USE THEREOF Catalent Ontario Limited (CA) 2026-04-15 EP claimed
EP-4722714-A1 SIMULTANEOUS ANALYSIS OF FOOD-BORNE DOPING SUBSTANCES USING LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY (VFD: VACCINE FOR FOODBORNE DOPING) Korea Institute of Science and Technology (KR) 2026-04-08 EP claimed
US-12576124-B2 Formulation of a conjugate of a tubulysin analog to a cell-binding molecule HANGZHOU DAC BIOTECH CO., LTD (CN) 2026-03-17 US claimed
EP-3820479-B1 METHODS TO REDUCE COMPLICATIONS OF INTRA-ARTICULAR STEROID TAIWAN LIPOSOME CO LTD (TW) 2026-03-11 EP claimed
EP-4689067-A2 CLINICAL-GRADE ORGANOIDS Children's Hospital Medical Center (US) 2026-02-11 EP claimed
EP-4683679-A1 METHOD FOR DIAGNOSING AND TREATING NIS-EXPRESSING CARCINOMAS AND METASTASES NUSKE, Andreas (DE) 2026-01-28 EP claimed
US-4474752-A DIAMINE MODIFIED POLYOXYETHYLENE-POLYOXYPROPYLENE COPOLYMER MERCK & CO., INC. (US) 1984-10-02 US claimed
US-4474753-A POLYETHERAMINE MERCK & CO., INC. (US) 1984-10-02 US claimed
US-4474751-A SUSTAINED RELEASE USING AN ALKYLENEDIAMINE-MODIFIED ETHYLENE OXIDE-PROPYLENE OXIDE COPOLYMER MERCK & CO., INC. (US) 1984-10-02 US claimed
US-4427670-A CONTAINING CORTICOSTEROID, PHOSPHATIDE, AND BUTYLHYDROXYANISOLE, OR BUTYLHYDROXYTOLUENE MITSUBISHI CHEMICAL INDUSTRIES LIMITED (JP) 1984-01-24 US claimed
US-4376767-A ANTIBIOTICS AND PHARMACEUTICALS MERCK & CO., INC. (US) 1983-03-15 US claimed
EP-0068553-A1 Topical antimicrobial anti-inflammatory compositions THE PROCTER & GAMBLE COMPANY (US) 1983-01-05 EP claimed
US-4343798-A Topical antimicrobial anti-inflammatory compositions THE PROCTER & GAMBLE COMPANY (US) 1982-08-10 US claimed
EP-0055870-A1 Pyridylmethyl esters of selected bio-affecting carboxylic acids, process for preparing and pharmaceutical composition comprising the same MERCK & CO. INC. (US) 1982-07-14 EP claimed
EP-0051278-A1 Soft tertiary amine esters of bio-affecting carboxylic acids, processes for preparing and a pharmaceutical composition containing the same MERCK & CO. INC. (US) 1982-05-12 EP claimed
US-4011317-A STEROID DERIVATIVES RORER ITALIANA S.P.A. (IT) 1977-03-08 US claimed