Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 1/20 | 0.48 |
| ▸ | CTSB | P07858 | 1/20 | 0.48 |
| ▸ | CTSK | P43235 | 1/20 | 0.48 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.41 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.41 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | NAAA | Q02083 | 1/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3058053 | 0.78 | CTSL (0.43) | CTSLCTSBCTSKNAAATAAR1 | |
| SCHEMBL27685353 | 0.73 | CTSK (0.56) | CTSLCTSBCTSKCHRNB2CHRNB4 | |
| SCHEMBL22616971 | 0.71 | CTSL (0.53) | CTSLCTSBCTSKCHRNB2CHRNB4 | |
| SCHEMBL22616969 | 0.71 | CTSL (0.53) | CTSLCTSBCTSKCHRNB2CHRNB4 | |
| SCHEMBL22616980 | 0.71 | CTSL (0.53) | CTSLCTSBCTSKCHRNB2CHRNB4 | |
| SCHEMBL6649338 | 0.71 | TSHR (0.54) | CTSLCTSBCTSKNAAATAAR1 | |
| SCHEMBL4677170 | 0.71 | TSHR (0.54) | CTSLCTSBCTSKNAAATAAR1 | |
| SCHEMBL1700657 | 0.70 | CTSL (0.45) | CTSLCTSBCTSKNAAATAAR1 | |
| SCHEMBL2701945 | 0.70 | CTSL (0.53) | CTSLCTSBCTSKNAAATAAR1 | |
| Hydrochloric Acid SCHEMBL5516807 | 0.69 | CTSL (0.44) | CTSLCTSBCTSKNAAATAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1960360-A1 | AZETIDINE DERIVATIVES AS GLYT1 INHIBITORS | MERCK SHARP & DOHME LTD. (GB) | 2008-08-27 | — | — | EP | disclosed |
| WO-2007060484-A1 | AZETIDINE DERIVATIVES AS GLYT1 INHIBITORS | MERCK SHARP & DOHME LIMITED (GB) | 2007-05-31 | — | — | WO | disclosed |