Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | GRM2 | Q14416 | 5/20 | 0.40 |
| ▸ | PNKP | Q96T60 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.39 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.39 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8790545 | 0.78 | MEN1 (0.48) | MEN1KMT2ANPC1RAB9AGRM2 | |
| SCHEMBL3841236 | 0.69 | ROCK2 (0.46) | MEN1KMT2ANPC1RAB9AGRM2 | |
| SCHEMBL12616867 | 0.68 | GRM2 (0.40) | NPC1GRM2ALOX5DDB1CRBN | |
| SCHEMBL21822034 | 0.67 | NPC1 (0.46) | MEN1KMT2ANPC1ALDH1A1HPGD | |
| SCHEMBL15319458 | 0.67 | DDB1 (0.41) | MEN1KMT2ANPC1RAB9ADDB1 | |
| SCHEMBL15319457 | 0.67 | DDB1 (0.41) | MEN1KMT2ANPC1RAB9ADDB1 | |
| SCHEMBL4645724 | 0.67 | GRM2 (0.41) | MEN1KMT2ANPC1RAB9AGRM2 | |
| SCHEMBL27766792 | 0.67 | DDB1 (0.40) | MEN1KMT2ANPC1RAB9AALOX5 | |
| SCHEMBL28849120 | 0.66 | ROCK2 (0.46) | MEN1KMT2ANPC1RAB9ADDB1 | |
| SCHEMBL5872162 | 0.66 | MEN1 (0.42) | MEN1KMT2ANPC1RAB9APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1885694-A2 | 4-BIARYLYL-1-PHENYLAZETIDIN-2-ONES | Microbia, Inc. (US) | 2008-02-13 | — | — | EP | disclosed |
| WO-2006124713-A2 | 4-BIARYLYL-1-PHENYLAZETIDIN-2-ONES | MICROBIA, INC. (US) | 2006-11-23 | — | — | WO | disclosed |
| EP-1682499-A1 | 4-BIARYLYL-1-PHENYLAZETIDIN-2-ONES | Microbia, Inc. (US) | 2006-07-26 | — | — | EP | disclosed |
| WO-2005047248-A1 | 4-BIARYLYL-1-PHENYLAZETIDIN-2-ONES | MICROBIA, INC. (US) | 2005-05-26 | — | — | WO | disclosed |