Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.38 |
| ▸ | NOS1 | P29475 | 1/20 | 0.38 |
| ▸ | NOS2 | P35228 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.37 |
| ▸ | GPR174 | Q9BXC1 | 1/20 | 0.37 |
| ▸ | KIT | P10721 | 1/20 | 0.36 |
| ▸ | STAT3 | P40763 | 1/20 | 0.36 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4649370 | 0.90 | MAPT (0.49) | MAPTALDH1A1SMN1; SMN2LMNAPOLB | |
| SCHEMBL4647377 | 0.89 | MAPT (0.46) | MAPTALDH1A1SMN1; SMN2LMNAPOLB | |
| SCHEMBL4648849 | 0.88 | MAPT (0.48) | MAPTALDH1A1SMN1; SMN2LMNAPOLB | |
| SCHEMBL4647785 | 0.87 | MAPT (0.51) | MAPTALDH1A1SMN1; SMN2LMNAPOLB | |
| SCHEMBL4646560 | 0.86 | ALDH1A1 (0.47) | MAPTALDH1A1SMN1; SMN2LMNAPOLB | |
| SCHEMBL4647964 | 0.85 | EPHX2 (0.40) | MAPTALDH1A1SMN1; SMN2LMNAMAPK1 | |
| SCHEMBL4750089 | 0.85 | MAPT (0.51) | MAPTALDH1A1SMN1; SMN2LMNAPOLB | |
| SCHEMBL4647625 | 0.83 | MAPT (0.47) | MAPTALDH1A1SMN1; SMN2LMNAPOLB | |
| SCHEMBL4648002 | 0.81 | MAPT (0.51) | MAPTALDH1A1SMN1; SMN2LMNAPOLB | |
| SCHEMBL4649093 | 0.81 | MAPT (0.48) | MAPTALDH1A1SMN1; SMN2LMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1960389-A2 | COMPOUNDS WHICH HAVE ACTIVITY AT M1 RECEPTOR AND THEIR USES IN MEDICINE | GLAXO GROUP LIMITED (GB) | 2008-08-27 | — | — | EP | disclosed |
| WO-2007036718-A2 | COMPOUNDS WHICH HAVE ACTIVITY AT M1 RECEPTOR AND THEIR USES IN MEDICINE | GLAXO GROUP LIMITED (GB) | 2007-04-05 | — | — | WO | disclosed |