Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | NOS1 | P29475 | 2/20 | 0.42 |
| ▸ | NOS2 | P35228 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.39 |
| ▸ | GPR174 | Q9BXC1 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | NOS3 | P29474 | 1/20 | 0.39 |
| ▸ | KIT | P10721 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4750089 | 0.96 | MAPT (0.51) | MAPTSMN1; SMN2ALDH1A1LMNAPOLB | |
| SCHEMBL4648849 | 0.90 | MAPT (0.48) | MAPTSMN1; SMN2ALDH1A1LMNAPOLB | |
| SCHEMBL4646565 | 0.87 | MAPT (0.46) | MAPTSMN1; SMN2ALDH1A1LMNAPOLB | |
| SCHEMBL4648002 | 0.86 | MAPT (0.51) | MAPTSMN1; SMN2ALDH1A1LMNAPOLB | |
| SCHEMBL4647625 | 0.86 | MAPT (0.47) | MAPTSMN1; SMN2ALDH1A1LMNAPOLB | |
| SCHEMBL4647157 | 0.85 | MAPT (0.49) | MAPTSMN1; SMN2ALDH1A1LMNAPOLB | |
| SCHEMBL4661126 | 0.84 | MAPT (0.52) | MAPTSMN1; SMN2ALDH1A1LMNAPOLB | |
| SCHEMBL4647282 | 0.84 | MAPT (0.49) | MAPTSMN1; SMN2ALDH1A1LMNAPOLB | |
| SCHEMBL4649370 | 0.84 | MAPT (0.49) | MAPTSMN1; SMN2ALDH1A1LMNAPOLB | |
| SCHEMBL4647407 | 0.84 | NOS2 (0.44) | MAPTSMN1; SMN2ALDH1A1LMNANOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1960389-A2 | COMPOUNDS WHICH HAVE ACTIVITY AT M1 RECEPTOR AND THEIR USES IN MEDICINE | GLAXO GROUP LIMITED (GB) | 2008-08-27 | — | — | EP | disclosed |
| WO-2007036718-A2 | COMPOUNDS WHICH HAVE ACTIVITY AT M1 RECEPTOR AND THEIR USES IN MEDICINE | GLAXO GROUP LIMITED (GB) | 2007-04-05 | — | — | WO | disclosed |