Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 5/20 | 0.47 |
| ▸ | LTA4H | P09960 | 2/20 | 0.47 |
| ▸ | ALOX5 | P09917 | 4/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.46 |
| ▸ | LAP3 | P28838 | 1/20 | 0.46 |
| ▸ | PPARG | P37231 | 4/20 | 0.46 |
| ▸ | PPARA | Q07869 | 3/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.44 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.44 |
| ▸ | PPARD | Q03181 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4221112 | 0.89 | MEN1 (0.39) | PTGS1L3MBTL1 | |
| SCHEMBL2176148 | 0.89 | MEN1 (0.39) | PTGS1L3MBTL1 | |
| SCHEMBL4510553 | 0.89 | MEN1 (0.39) | PTGS1L3MBTL1 | |
| SCHEMBL718201 | 0.89 | MEN1 (0.39) | PTGS1L3MBTL1 | |
| SCHEMBL4234514 | 0.78 | ALOX5 (0.55) | MAOBLTA4HALOX5PTGS1PTGS2 | |
| SCHEMBL771564 | 0.77 | MAOB (0.51) | MAOBLTA4HALOX5PTGS1PTGS2 | |
| SCHEMBL970613 | 0.77 | TAS2R14 (0.37) | — | |
| SCHEMBL771563 | 0.77 | MAOB (0.51) | MAOBLTA4HALOX5PTGS1PTGS2 | |
| SCHEMBL2492807 | 0.76 | MAOB (0.53) | MAOBLTA4HALOX5PTGS1PTGS2 | |
| SCHEMBL5391773 | 0.76 | NAPRT (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1686113-B1 | Inhibitors of aspartyl protease | VERTEX PHARMA (US) | 2011-11-23 | — | — | EP | disclosed |