Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 3/20 | 0.65 |
| ▸ | PPARG | P37231 | 3/20 | 0.60 |
| ▸ | BCL2 | P10415 | 1/20 | 0.59 |
| ▸ | ITGB3 | P05106 | 3/20 | 0.59 |
| ▸ | ITGA2B | P08514 | 3/20 | 0.59 |
| ▸ | ACE | P12821 | 2/20 | 0.57 |
| ▸ | YAP1 | P46937 | 1/20 | 0.56 |
| ▸ | PPARA | Q07869 | 2/20 | 0.55 |
| ▸ | MME | P08473 | 1/20 | 0.54 |
| ▸ | CPA1 | P15085 | 1/20 | 0.54 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.54 |
| ▸ | GPR34 | Q9UPC5 | 1/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.52 |
| ▸ | REN | P00797 | 1/20 | 0.51 |
| ▸ | CTSS | P25774 | 2/20 | 0.51 |
| ▸ | CTSL | P07711 | 1/20 | 0.51 |
| ▸ | CTSB | P07858 | 1/20 | 0.51 |
| ▸ | CTSK | P43235 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL193474 | 0.93 | PTPN1 (0.73) | PTPN1PPARGBCL2ITGB3ITGA2B | |
| SCHEMBL193473 | 0.93 | PTPN1 (0.73) | PTPN1PPARGBCL2ITGB3ITGA2B | |
| SCHEMBL2891538 | 0.93 | PTPN1 (0.73) | PTPN1PPARGBCL2ITGB3ITGA2B | |
| SCHEMBL28267499 | 0.88 | PTPN1 (0.77) | PTPN1PPARGBCL2ITGB3ITGA2B | |
| SCHEMBL28267496 | 0.88 | PTPN1 (0.77) | PTPN1PPARGBCL2ITGB3ITGA2B | |
| SCHEMBL12706402 | 0.86 | BCL2 (0.62) | PTPN1PPARGBCL2ITGB3ITGA2B | |
| SCHEMBL27575100 | 0.86 | BCL2 (0.59) | PTPN1PPARGBCL2ITGB3ITGA2B | |
| SCHEMBL7320039 | 0.84 | ACE (0.58) | PTPN1PPARGBCL2ITGB3ITGA2B | |
| Phenylalanine Methyl Ester SCHEMBL28119144 | 0.84 | PTPN1 (0.63) | PTPN1PPARGBCL2ITGB3ITGA2B | |
| SCHEMBL6161729 | 0.84 | BCL2 (0.64) | PTPN1PPARGBCL2ITGB3ITGA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8455497-B2 | Inhibitors of aspartyl protease | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-06-04 | — | — | US | disclosed |
| EP-1686113-B1 | Inhibitors of aspartyl protease | VERTEX PHARMA (US) | 2011-11-23 | — | — | EP | disclosed |
| US-20090274650-A1 | INHIBITORS OF ASPARTYL PROTEASE | VERTEX PHARMACEUTICALS INCORPORATED | 2009-11-05 | — | — | US | disclosed |
| EP-1686113-A1 | Inhibitors of aspartyl protease | Vertex Pharmaceuticals Incorporated (US) | 2006-08-02 | — | — | EP | disclosed |
| EP-1194404-B1 | INHIBITORS OF ASPARTYL PROTEASE | VERTEX PHARMA (US) | 2006-05-03 | — | — | EP | disclosed |
| US-6878728-B1 | Inhibitors of aspartyl protease | VERTEX PHARMACEUTICAL INCORPORATED (US) | 2005-04-12 | — | — | US | disclosed |
| US-20040122000-A1 | Inhibitors of aspartyl protease | VERTEX PHARMACEUTICALS INCORPORATED. | 2004-06-24 | — | — | US | disclosed |
| EP-1194404-A1 | INHIBITORS OF ASPARTYL PROTEASE | Vertex Pharmaceuticals Incorporated (US) | 2002-04-10 | — | — | EP | disclosed |
| WO-2000076961-A1 | INHIBITORS OF ASPARTYL PROTEASE | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2000-12-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040122000-A1 | Inhibitors of aspartyl protease | SPINT2, DNPEP, PRSS1 | PTPN1 1557/4885PPARG 4753/4885BCL2 1781/4885 |
| US-20090274650-A1 | INHIBITORS OF ASPARTYL PROTEASE | SPINT2, DNPEP, PRSS1 | PTPN1 1557/4885PPARG 4753/4885BCL2 1781/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.