Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.32 |
| ▸ | DAO | P14920 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4648190 | 0.84 | HCAR2 (0.32) | MAPTMEN1KMT2APOLBHCAR2 | |
| SCHEMBL4648277 | 0.81 | KMT2A (0.42) | MAPTMEN1KMT2APOLBNPC1 | |
| SCHEMBL4646927 | 0.64 | KDM4C (0.52) | MEN1KMT2ANPC1HCAR2DAO | |
| SCHEMBL4648477 | 0.63 | MEN1 (0.39) | MAPTMEN1KMT2APOLBHCAR2 | |
| SCHEMBL9634678 | 0.61 | MAPT (0.30) | MAPT | |
| SCHEMBL4647495 | 0.60 | HCAR3 (0.49) | MAPTMEN1KMT2APOLBSMN1; SMN2 | |
| SCHEMBL570055 | 0.59 | MAPT (1.00) | MAPTMEN1KMT2APOLBNPC1 | |
| SCHEMBL3516314 | 0.59 | MEN1 (0.55) | MAPTMEN1KMT2APOLBHCAR2 | |
| SCHEMBL18233041 | 0.58 | KMT2A (0.55) | KMT2APOLBNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL13933304 | 0.58 | HCAR2 (0.53) | HCAR2DAOL3MBTL1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899304-A1 | 5-AMINO-1H-PYRAZOLE-3-CARBOXYLIC ACID DERIVATIVES AS AGONISTS FOR THE G-PROTEIN COUPLED RECEPTOR (GPCR) RUP38 FOR THE TREATMENT OF METABOLIC-RELATED DISORDERS THEREOF | Arena Pharmaceuticals, Inc. (US) | 2008-03-19 | — | — | EP | disclosed |
| WO-2006127595-A1 | 5-AMINOPYRAZOLE CARBOXYLIC ACID DERIVATIVES AND METHODS OF TREATMENT OF METABOLIC-RELATED DISORDERS THEREOF | ARENA PHARMACEUTICALS, INC. (US) | 2006-11-30 | — | — | WO | disclosed |