Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 8/20 | 0.79 |
| ▸ | BRAF | P15056 | 10/20 | 0.54 |
| ▸ | KCNJ6 | P48051 | 2/20 | 0.53 |
| ▸ | KCNJ5 | P48544 | 2/20 | 0.53 |
| ▸ | KCNJ3 | P48549 | 2/20 | 0.53 |
| ▸ | SRC | P12931 | 2/20 | 0.49 |
| ▸ | SYK | P43405 | 2/20 | 0.49 |
| ▸ | GSK3A | P49840 | 1/20 | 0.49 |
| ▸ | PLK4 | O00444 | 1/20 | 0.48 |
| ▸ | ACOX3 | O15254 | 1/20 | 0.48 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.48 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.48 |
| ▸ | JAK2 | O60674 | 1/20 | 0.48 |
| ▸ | ERN1 | O75460 | 1/20 | 0.48 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.48 |
| ▸ | STK10 | O94804 | 1/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.48 |
| ▸ | ABL1 | P00519 | 1/20 | 0.48 |
| ▸ | RAF1 | P04049 | 1/20 | 0.48 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4649353 | 0.91 | MAPK14 (0.66) | MAPK14BRAFKCNJ6KCNJ5KCNJ3 | |
| SCHEMBL4686310 | 0.91 | MAPK14 (0.65) | MAPK14BRAFSRCSYKPLK4 | |
| SCHEMBL16749182 | 0.89 | MAPK14 (1.00) | MAPK14BRAFSRCSYKPLK4 | |
| SCHEMBL29844334 | 0.89 | MAPK14 (1.00) | MAPK14BRAFSRCSYKPLK4 | |
| SCHEMBL4787983 | 0.87 | MAPK14 (0.61) | MAPK14BRAFKCNJ6KCNJ5KCNJ3 | |
| SCHEMBL2025093 | 0.86 | MAPK14 (0.65) | MAPK14BRAFSRCSYKGSK3A | |
| SCHEMBL4648264 | 0.85 | MAPK14 (0.59) | MAPK14BRAFSRCSYKPLK4 | |
| SCHEMBL14538023 | 0.85 | MAPK14 (0.84) | MAPK14BRAFSRCSYKPLK4 | |
| SCHEMBL5055024 | 0.84 | MAPK14 (0.58) | MAPK14BRAFKCNJ6KCNJ5KCNJ3 | |
| SCHEMBL2244656 | 0.84 | MAPK14 (0.58) | MAPK14BRAFKCNJ6KCNJ5KCNJ3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1960394-A2 | PYRAZOLYL UREA DERIVATIVES USEFUL IN THE TREATMENT OF CANCER | Bayer HealthCare AG (DE) | 2008-08-27 | — | — | EP | disclosed |
| WO-2007059202-A2 | PYRAZOLYL UREA DERIVATIVES USEFUL IN THE TREATMENT OF CANCER | BAYER HEALTHCARE AG (DE) | 2007-05-24 | — | — | WO | disclosed |
| WO-2007059202-A2 | PYRAZOLYL UREA DERIVATIVES USEFUL IN THE TREATMENT OF CANCER | BAYER HEALTHCARE AG (DE) | 2007-05-24 | — | — | WO | disclosed |