Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 5/20 | 0.66 |
| ▸ | KCNJ6 | P48051 | 5/20 | 0.58 |
| ▸ | KCNJ5 | P48544 | 5/20 | 0.58 |
| ▸ | KCNJ3 | P48549 | 5/20 | 0.58 |
| ▸ | BRAF | P15056 | 5/20 | 0.55 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.52 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.52 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.52 |
| ▸ | CDK8 | P49336 | 2/20 | 0.48 |
| ▸ | RAF1 | P04049 | 3/20 | 0.47 |
| ▸ | SRC | P12931 | 1/20 | 0.46 |
| ▸ | SYK | P43405 | 1/20 | 0.46 |
| ▸ | GSK3A | P49840 | 1/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | AXL | P30530 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4647702 | 0.91 | MAPK14 (0.79) | MAPK14KCNJ6KCNJ5KCNJ3BRAF | |
| SCHEMBL4648705 | 0.91 | BRAF (0.55) | MAPK14KCNJ6KCNJ5KCNJ3BRAF | |
| SCHEMBL4648837 | 0.87 | MAPK14 (0.82) | MAPK14BRAFMAPK13MAPK12MAPK11 | |
| SCHEMBL4695418 | 0.86 | BRAF (0.56) | MAPK14KCNJ6KCNJ5KCNJ3BRAF | |
| SCHEMBL4648543 | 0.86 | KCNJ6 (0.63) | MAPK14KCNJ6KCNJ5KCNJ3BRAF | |
| SCHEMBL5054691 | 0.84 | KCNJ6 (0.52) | MAPK14KCNJ6KCNJ5KCNJ3BRAF | |
| SCHEMBL5056499 | 0.84 | KDR (0.56) | MAPK14KCNJ6KCNJ5KCNJ3BRAF | |
| SCHEMBL4648831 | 0.83 | BRAF (0.53) | MAPK14KCNJ6KCNJ5KCNJ3BRAF | |
| SCHEMBL2239098 | 0.83 | BRAF (0.53) | MAPK14KCNJ6KCNJ5KCNJ3BRAF | |
| SCHEMBL2242902 | 0.82 | KCNJ6 (0.57) | MAPK14KCNJ6KCNJ5KCNJ3BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1960394-A2 | PYRAZOLYL UREA DERIVATIVES USEFUL IN THE TREATMENT OF CANCER | Bayer HealthCare AG (DE) | 2008-08-27 | — | — | EP | disclosed |
| WO-2007059202-A2 | PYRAZOLYL UREA DERIVATIVES USEFUL IN THE TREATMENT OF CANCER | BAYER HEALTHCARE AG (DE) | 2007-05-24 | — | — | WO | disclosed |
| WO-2007059202-A2 | PYRAZOLYL UREA DERIVATIVES USEFUL IN THE TREATMENT OF CANCER | BAYER HEALTHCARE AG (DE) | 2007-05-24 | — | — | WO | disclosed |