Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | DHODH | Q02127 | 1/20 | 0.35 |
| ▸ | HCAR2 | Q8TDS4 | 4/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | TACR1 | P25103 | 1/20 | 0.34 |
| ▸ | FAAH | O00519 | 1/20 | 0.34 |
| ▸ | P4HB | P07237 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4648180 | 0.69 | KDM4C (0.45) | KDM4CPOLBMAPTMEN1KMT2A | |
| SCHEMBL4648274 | 0.68 | MEN1 (0.52) | POLBMAPTMEN1KMT2ARAB9A | |
| SCHEMBL4648548 | 0.67 | MEN1 (0.39) | POLBMAPTMEN1KMT2AHCAR2 | |
| SCHEMBL29442138 | 0.65 | KDM4C (0.52) | KDM4CPOLBALDH1A1DHODHCDK2 | |
| SCHEMBL340702 | 0.65 | KDM4C (0.52) | KDM4CPOLBALDH1A1DHODHCDK2 | |
| SCHEMBL7687089 | 0.65 | ALDH1A1 (0.42) | KDM4CPOLBALDH1A1TACR1FAAH | |
| SCHEMBL4648477 | 0.64 | MEN1 (0.39) | POLBMAPTMEN1KMT2AHCAR2 | |
| SCHEMBL4473207 | 0.64 | ALDH1A1 (0.46) | KDM4CPOLBALDH1A1TACR1PPARG | |
| Hydrochloric Acid SCHEMBL9236405 | 0.64 | KDM4C (0.51) | KDM4CPOLBALDH1A1CDK2FAAH | |
| SCHEMBL6948312 | 0.63 | ALDH1A1 (0.41) | KDM4CPOLBALDH1A1TACR1FAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899304-A1 | 5-AMINO-1H-PYRAZOLE-3-CARBOXYLIC ACID DERIVATIVES AS AGONISTS FOR THE G-PROTEIN COUPLED RECEPTOR (GPCR) RUP38 FOR THE TREATMENT OF METABOLIC-RELATED DISORDERS THEREOF | Arena Pharmaceuticals, Inc. (US) | 2008-03-19 | — | — | EP | claimed |
| WO-2006127595-A1 | 5-AMINOPYRAZOLE CARBOXYLIC ACID DERIVATIVES AND METHODS OF TREATMENT OF METABOLIC-RELATED DISORDERS THEREOF | ARENA PHARMACEUTICALS, INC. (US) | 2006-11-30 | — | — | WO | claimed |