Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HCAR2 | Q8TDS4 | 11/20 | 0.38 |
| ▸ | HCAR3 | P49019 | 2/20 | 0.38 |
| ▸ | DAO | P14920 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | CYTH3 | O43739 | 1/20 | 0.35 |
| ▸ | BTK | Q06187 | 1/20 | 0.35 |
| ▸ | EPN1 | Q9Y6I3 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4648477 | 0.76 | MEN1 (0.39) | MEN1KMT2APOLBMAPTHCAR2 | |
| SCHEMBL4648274 | 0.71 | MEN1 (0.52) | MEN1KMT2APOLBMAPTHCAR2 | |
| SCHEMBL4648167 | 0.67 | KDM4C (0.42) | MEN1KMT2APOLBMAPTHCAR2 | |
| SCHEMBL4649871 | 0.65 | HCAR3 (0.58) | HCAR2HCAR3DAOCYTH3BTK | |
| SCHEMBL4648610 | 0.64 | HCAR2 (0.47) | HCAR2HCAR3DAOCYTH3BTK | |
| SCHEMBL13933304 | 0.63 | HCAR2 (0.53) | HCAR2HCAR3DAOCYTH3BTK | |
| SCHEMBL4648554 | 0.62 | HCAR3 (0.61) | MEN1KMT2APOLBMAPTHCAR2 | |
| SCHEMBL5008289 | 0.62 | CCNA2 (0.51) | MEN1KMT2AMAPTHCAR2 | |
| SCHEMBL4623217 | 0.62 | HCAR2 (0.58) | HCAR2DAO | |
| SCHEMBL5279554 | 0.60 | HCAR2 (0.49) | MAPTHCAR2HCAR3DAOMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899304-A1 | 5-AMINO-1H-PYRAZOLE-3-CARBOXYLIC ACID DERIVATIVES AS AGONISTS FOR THE G-PROTEIN COUPLED RECEPTOR (GPCR) RUP38 FOR THE TREATMENT OF METABOLIC-RELATED DISORDERS THEREOF | Arena Pharmaceuticals, Inc. (US) | 2008-03-19 | — | — | EP | disclosed |
| WO-2006127595-A1 | 5-AMINOPYRAZOLE CARBOXYLIC ACID DERIVATIVES AND METHODS OF TREATMENT OF METABOLIC-RELATED DISORDERS THEREOF | ARENA PHARMACEUTICALS, INC. (US) | 2006-11-30 | — | — | WO | disclosed |