Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.51 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.48 |
| ▸ | PLK1 | P53350 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | PPARG | P37231 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.47 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | GRM5 | P41594 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 4/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.42 |
| ▸ | RELA | Q04206 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28687700 | 0.81 | GRM5 (0.59) | L3MBTL1RXFP1KMT2APPARGTDP1 | |
| SCHEMBL7207983 | 0.81 | KMT2A (0.62) | L3MBTL1RXFP1KMT2APPARGTDP1 | |
| SCHEMBL14033011 | 0.78 | L3MBTL1 (0.46) | L3MBTL1RXFP1KMT2APPARGTDP1 | |
| SCHEMBL10655608 | 0.76 | RAB9A (0.46) | L3MBTL1RXFP1PLK1KMT2AGRM5 | |
| SCHEMBL17541672 | 0.74 | PTK2 (0.51) | L3MBTL1KMT2APOLBGRM5MEN1 | |
| SCHEMBL2244112 | 0.73 | NPC1 (0.64) | PLK1KMT2ATDP1RAB9ANPC1 | |
| SCHEMBL15881317 | 0.72 | GRM5 (0.48) | L3MBTL1RXFP1KMT2APPARGTDP1 | |
| SCHEMBL4644302 | 0.71 | RAB9A (0.58) | KMT2APOLBRAB9ANPC1TP53 | |
| SCHEMBL17617988 | 0.71 | TYK2 (0.48) | L3MBTL1GRM5SMN1; SMN2 | |
| SCHEMBL28160772 | 0.71 | GRM5 (0.44) | L3MBTL1KMT2APPARGTDP1NR2E3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1675830-A4 | HETEROCYCLIC AMIDES AND SULFONAMIDES | SCIOS INC (US) | 2008-08-20 | — | — | EP | disclosed |
| US-20060199821-A1 | Heterocyclic amides and sulfonamides | SCIOS, INC. (US) | 2006-09-07 | — | — | US | disclosed |
| EP-1675830-A2 | HETEROCYCLIC AMIDES AND SULFONAMIDES | SCIOS INC. (US) | 2006-07-05 | — | — | EP | disclosed |
| WO-2005033072-A2 | HETEROCYCLIC AMIDES AND SULFONAMIDES | SCIOS INC. (US) | 2005-04-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060199821-A1 | Heterocyclic amides and sulfonamides | MAP4K2, MAP3K8, MAP3K2 | L3MBTL1 3403/4885RXFP1 3827/4885PLK1 333/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.