Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.42 |
| ▸ | NQO2 | P16083 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | PADI4 | Q9UM07 | 1/20 | 0.40 |
| ▸ | KDM5A | P29375 | 1/20 | 0.38 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL322275 | 0.78 | USP2 (0.44) | USP2KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL14335867 | 0.76 | USP2 (0.44) | USP2CYP19A1NQO2KDM4EALDH1A1 | |
| SCHEMBL16098758 | 0.73 | USP2 (0.44) | USP2KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL18073576 | 0.70 | CYP19A1 (0.46) | CYP19A1NQO2KDM4EALDH1A1HPGD | |
| SCHEMBL30681958 | 0.70 | KDM4E (0.71) | KDM4EALDH1A1MEN1KMT2AHPGD | |
| SCHEMBL1622313 | 0.70 | KDM4E (0.71) | KDM4EALDH1A1MEN1KMT2AHPGD | |
| SCHEMBL9515279 | 0.70 | KDM4E (0.39) | KDM4EALDH1A1KMT2AHPGDHSD17B10 | |
| SCHEMBL3986764 | 0.69 | MEN1 (0.47) | USP2KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL8018550 | 0.69 | MEN1 (0.64) | ALDH1A1MEN1KMT2A | |
| SCHEMBL30037913 | 0.69 | MEN1 (0.64) | ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1960363-A2 | QUINOLONE BASED COMPOUNDS EXHIBITING PROLYL HYDROXYLASE INHIBITORY ACTIVITY, AND COMPOSITIONS, AND USES THEREOF | Amgen, Inc. (US) | 2008-08-27 | — | — | EP | disclosed |
| WO-2007070359-A2 | QUINOLONE BASED COMPOUNDS EXHIBITING PROLYL HYDROXYLASE INHIBITORY ACTIVITY, AND COMPOSITIONS, AND USES THEREOF | AMGEN INC. (US) | 2007-06-21 | — | — | WO | disclosed |