Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 8/20 | 0.57 |
| ▸ | KCNJ6 | P48051 | 8/20 | 0.48 |
| ▸ | KCNJ3 | P48549 | 8/20 | 0.48 |
| ▸ | KCNJ5 | P48544 | 6/20 | 0.48 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | BRAF | P15056 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4787983 | 0.86 | MAPK14 (0.61) | MAPK14KCNJ6KCNJ3KCNJ5MAPK13 | |
| SCHEMBL4647983 | 0.85 | KCNJ6 (0.66) | MAPK14KCNJ6KCNJ3KCNJ5BRAF | |
| SCHEMBL2246430 | 0.83 | KCNJ6 (0.47) | MAPK14KCNJ6KCNJ3KCNJ5KDR | |
| SCHEMBL14538024 | 0.81 | KCNJ6 (0.47) | MAPK14KCNJ6KCNJ3KCNJ5MAPK13 | |
| SCHEMBL4745379 | 0.80 | MAPK14 (0.66) | MAPK14KCNJ6KCNJ3KCNJ5MAPK13 | |
| SCHEMBL2242576 | 0.79 | ABL1 (0.60) | MAPK14KCNJ6KCNJ3KCNJ5KDR | |
| SCHEMBL2243747 | 0.79 | ABL1 (0.58) | MAPK14KCNJ6KCNJ3KCNJ5MAPK13 | |
| SCHEMBL2240618 | 0.79 | ABL1 (0.58) | MAPK14KCNJ6KCNJ3KCNJ5MAPK13 | |
| SCHEMBL4686310 | 0.79 | MAPK14 (0.65) | MAPK14MAPK13KDRBRAF | |
| SCHEMBL2243890 | 0.78 | MAPK14 (0.51) | MAPK14KCNJ6KCNJ3KCNJ5MAPK13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1960394-A2 | PYRAZOLYL UREA DERIVATIVES USEFUL IN THE TREATMENT OF CANCER | Bayer HealthCare AG (DE) | 2008-08-27 | — | — | EP | disclosed |
| WO-2007059202-A2 | PYRAZOLYL UREA DERIVATIVES USEFUL IN THE TREATMENT OF CANCER | BAYER HEALTHCARE AG (DE) | 2007-05-24 | — | — | WO | disclosed |