Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 4/20 | 0.55 |
| ▸ | MAPK14 | Q16539 | 7/20 | 0.53 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.53 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.53 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.53 |
| ▸ | KCNJ6 | P48051 | 5/20 | 0.52 |
| ▸ | KCNJ5 | P48544 | 5/20 | 0.52 |
| ▸ | KCNJ3 | P48549 | 5/20 | 0.52 |
| ▸ | RAF1 | P04049 | 1/20 | 0.48 |
| ▸ | MET | P08581 | 2/20 | 0.46 |
| ▸ | CDK8 | P49336 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4695418 | 0.92 | BRAF (0.56) | BRAFMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL4648543 | 0.92 | KCNJ6 (0.63) | BRAFMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL4649353 | 0.91 | MAPK14 (0.66) | BRAFMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL4686310 | 0.90 | MAPK14 (0.65) | BRAFMAPK14MAPK13MAPK11RAF1 | |
| SCHEMBL4648831 | 0.89 | BRAF (0.53) | BRAFMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL4689912 | 0.87 | MAPK13 (0.68) | BRAFMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL4649081 | 0.87 | MAPK14 (0.53) | BRAFMAPK14MAPK13KCNJ6KCNJ5 | |
| SCHEMBL4787983 | 0.83 | MAPK14 (0.61) | BRAFMAPK14MAPK13MAPK11KCNJ6 | |
| SCHEMBL2239098 | 0.83 | BRAF (0.53) | BRAFMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL5054704 | 0.83 | AXL (0.60) | BRAFMAPK14MAPK13MAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1960394-A2 | PYRAZOLYL UREA DERIVATIVES USEFUL IN THE TREATMENT OF CANCER | Bayer HealthCare AG (DE) | 2008-08-27 | — | — | EP | disclosed |
| WO-2007059202-A2 | PYRAZOLYL UREA DERIVATIVES USEFUL IN THE TREATMENT OF CANCER | BAYER HEALTHCARE AG (DE) | 2007-05-24 | — | — | WO | disclosed |