Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 2/20 | 0.34 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.33 |
| ▸ | LTA4H | P09960 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.32 |
| ▸ | CFTR | P13569 | 1/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | SCD | O00767 | 1/20 | 0.31 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.31 |
| ▸ | USP9X | Q93008 | 2/20 | 0.30 |
| ▸ | RORC | P51449 | 1/20 | 0.30 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.30 |
| ▸ | CTSA | P10619 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4970705 | 0.81 | PDK2 (0.39) | HDAC4HDAC3HDAC1HDAC2 | |
| SCHEMBL981548 | 0.70 | EPHX2 (0.40) | HDAC4NTRK1 | |
| SCHEMBL983406 | 0.68 | EPHX2 (0.38) | — | |
| SCHEMBL18742726 | 0.62 | HDAC4 (0.63) | HDAC4HDAC6HDAC3HDAC1HDAC2 | |
| SCHEMBL625260 | 0.62 | TRPV3 (0.52) | HDAC4HDAC6HDAC3HDAC1HDAC2 | |
| SCHEMBL5789925 | 0.62 | MKNK2 (0.51) | HDAC4LTA4H | |
| SCHEMBL4968726 | 0.61 | HDAC4 (0.51) | HDAC4HDAC6HDAC3HDAC1HDAC2 | |
| SCHEMBL27907596 | 0.59 | HDAC4 (0.67) | HDAC4HDAC6HDAC3HDAC1HDAC2 | |
| SCHEMBL18741984 | 0.59 | CES1 (0.54) | HDAC4LTA4HUSP9X | |
| SCHEMBL15675358 | 0.59 | KIF11 (0.50) | LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1960351-A1 | PROPIONAMIDE COMPOUNDS AS ANTIINFLAMMATORY AGENTS | F.HOFFMANN-LA ROCHE AG (CH) | 2008-08-27 | — | — | EP | disclosed |
| WO-2007065821-A1 | PROPIONAMIDE COMPOUNDS AS ANTIINFLAMMATORY AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-06-14 | — | — | WO | disclosed |