Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 3/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.38 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.38 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.38 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ALKBH1 | Q13686 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4650790 | 0.87 | KDM5A (0.42) | ALDH1A1HPGDKDM4EHTTCSNK2A2 | |
| SCHEMBL4650011 | 0.86 | KDM4C (0.45) | ALDH1A1HPGDKDM4ERAB9ACSNK2A2 | |
| SCHEMBL4650143 | 0.84 | CSNK2A2 (0.43) | ALDH1A1HPGDKDM4ELMNACSNK2A2 | |
| SCHEMBL4559012 | 0.81 | CHRM1 (0.43) | ALDH1A1HPGDCSNK2A2CSNK2BCSNK2A1 | |
| SCHEMBL4650001 | 0.80 | CSNK2A2 (0.39) | ALDH1A1HPGDCSNK2A2CSNK2BCSNK2A1 | |
| SCHEMBL4649448 | 0.80 | CSNK2A1 (0.44) | ALDH1A1HPGDKDM4ELMNACSNK2A2 | |
| SCHEMBL4650109 | 0.80 | CYP1A2 (0.46) | ALDH1A1HPGDKDM4EHTTCSNK2A2 | |
| SCHEMBL4650040 | 0.78 | KDM4E (0.46) | ALDH1A1HPGDKDM4ELMNAHTT | |
| SCHEMBL4650643 | 0.78 | KDM5A (0.41) | ALDH1A1HPGDCSNK2A2CSNK2BCSNK2A1 | |
| SCHEMBL1126554 | 0.78 | CSNK2A2 (0.38) | ALDH1A1HPGDKDM4ECSNK2A2CSNK2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1963271-A1 | QUINOLONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | Merck & Co., Inc. (US) | 2008-09-03 | — | — | EP | claimed |
| WO-2007067489-A1 | QUINOLONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK & CO., INC. (US) | 2007-06-14 | — | — | WO | claimed |
| EP-1963271-A1 | QUINOLONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | Merck & Co., Inc. (US) | 2008-09-03 | — | — | EP | disclosed |
| WO-2007067489-A1 | QUINOLONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK & CO., INC. (US) | 2007-06-14 | — | — | WO | disclosed |