Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK2A1 | P68400 | 5/20 | 0.44 |
| ▸ | CSNK2A2 | P19784 | 4/20 | 0.44 |
| ▸ | CSNK2B | P67870 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | PRKAB2 | O43741 | 2/20 | 0.33 |
| ▸ | PRKAG1 | P54619 | 2/20 | 0.33 |
| ▸ | PRKAA2 | P54646 | 2/20 | 0.33 |
| ▸ | PRKAA1 | Q13131 | 2/20 | 0.33 |
| ▸ | PRKAG3 | Q9UGI9 | 2/20 | 0.33 |
| ▸ | PRKAG2 | Q9UGJ0 | 2/20 | 0.33 |
| ▸ | PRKAB1 | Q9Y478 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | MDH2 | P40926 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.33 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4650143 | 0.89 | CSNK2A2 (0.43) | CSNK2A1CSNK2A2CSNK2BKDM4ECYP1A2 | |
| SCHEMBL4650790 | 0.86 | KDM5A (0.42) | CSNK2A1CSNK2A2CSNK2BKDM4ECYP1A2 | |
| SCHEMBL4559012 | 0.84 | CHRM1 (0.43) | CSNK2A1CSNK2A2CSNK2BCYP1A2HSD17B10 | |
| SCHEMBL4650109 | 0.83 | CYP1A2 (0.46) | CSNK2A1CSNK2A2CSNK2BKDM4ECYP1A2 | |
| SCHEMBL4650035 | 0.82 | CSNK2A2 (0.43) | CSNK2A1CSNK2A2CSNK2BKDM4ECYP1A2 | |
| SCHEMBL4650001 | 0.81 | CSNK2A2 (0.39) | CSNK2A1CSNK2A2CSNK2BCYP1A2HSD17B10 | |
| SCHEMBL4650012 | 0.81 | PNP (0.41) | CSNK2A1CSNK2A2CSNK2BKDM4ECYP1A2 | |
| SCHEMBL1126554 | 0.80 | CSNK2A2 (0.38) | CSNK2A1CSNK2A2CSNK2BKDM4ECYP1A2 | |
| SCHEMBL4649980 | 0.80 | CYP1A2 (0.43) | CSNK2A1CSNK2A2CSNK2BCYP1A2HSD17B10 | |
| SCHEMBL4649199 | 0.80 | ALDH1A1 (0.43) | CSNK2A1CSNK2A2CSNK2BKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1963271-A1 | QUINOLONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | Merck & Co., Inc. (US) | 2008-09-03 | — | — | EP | disclosed |
| WO-2007067489-A1 | QUINOLONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK & CO., INC. (US) | 2007-06-14 | — | — | WO | disclosed |