Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | F10 | P00742 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | CCR2 | P41597 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | PLA2G2A | P14555 | 3/20 | 0.43 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.43 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4653186 | 0.92 | KMT2A (0.51) | KMT2ASMN1; SMN2MEN1LMNAHPGD | |
| SCHEMBL4649686 | 0.91 | KMT2A (0.50) | KMT2ASMN1; SMN2MEN1LMNAHPGD | |
| SCHEMBL4650163 | 0.90 | KMT2A (0.49) | KMT2ASMN1; SMN2MEN1LMNAHPGD | |
| SCHEMBL4653221 | 0.85 | F10 (0.59) | KMT2ASMN1; SMN2MEN1LMNAHPGD | |
| SCHEMBL6302415 | 0.79 | MAPT (0.51) | SMN1; SMN2LMNAF10MAPTKDM4E | |
| SCHEMBL6306975 | 0.78 | CCR2 (0.72) | SMN1; SMN2LMNAF10MAPTKDM4E | |
| SCHEMBL4653080 | 0.76 | F10 (0.45) | KMT2ASMN1; SMN2MEN1LMNAHPGD | |
| SCHEMBL6358543 | 0.76 | F10 (0.61) | KMT2ASMN1; SMN2MEN1LMNAF10 | |
| SCHEMBL4650061 | 0.75 | KMT2A (0.44) | KMT2ASMN1; SMN2MEN1LMNAHPGD | |
| SCHEMBL6307843 | 0.75 | NOD2 (0.74) | KMT2ASMN1; SMN2MEN1F10MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904487-A2 | INDOLE DERIVATIVES FOR THE TREATMENT OF TUBERCULOSIS | AstraZeneca AB (SE) | 2008-04-02 | — | — | EP | disclosed |
| WO-2006067392-A2 | INDOLE DERIVATIVES FOR THE TREATMENT OF TUBERCULOSIS | ASTRAZENECA AB (SE) | 2006-06-29 | — | — | WO | disclosed |