Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | WDR5 | P61964 | 6/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | MMP1 | P03956 | 2/20 | 0.36 |
| ▸ | MMP2 | P08253 | 2/20 | 0.36 |
| ▸ | MMP9 | P14780 | 2/20 | 0.36 |
| ▸ | MMP8 | P22894 | 2/20 | 0.36 |
| ▸ | MMP13 | P45452 | 2/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4648651 | 0.81 | MAPT (0.44) | ALDH1A1MAPTLMNAMEN1KMT2A | |
| SCHEMBL30369831 | 0.74 | MAPT (0.53) | ALDH1A1MAPTLMNAMEN1KMT2A | |
| SCHEMBL2831541 | 0.74 | MAPT (0.53) | ALDH1A1MAPTLMNAMEN1KMT2A | |
| SCHEMBL5383005 | 0.74 | ALDH1A1 (0.63) | ALDH1A1MAPTLMNAMEN1KMT2A | |
| SCHEMBL30116065 | 0.74 | ALDH1A1 (0.63) | ALDH1A1MAPTLMNAMEN1KMT2A | |
| SCHEMBL4646197 | 0.73 | ALDH1A1 (0.47) | ALDH1A1MAPTLMNAMEN1KMT2A | |
| SCHEMBL4645982 | 0.71 | POLB (0.38) | ALDH1A1MAPTLMNAMEN1KMT2A | |
| SCHEMBL4649202 | 0.69 | CYP17A1 (0.35) | DRD2 | |
| SCHEMBL25095983 | 0.68 | CYP17A1 (0.44) | ALDH1A1MAPTLMNAMEN1KMT2A | |
| SCHEMBL7008553 | 0.68 | CYP17A1 (0.44) | ALDH1A1MAPTLMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1667989-A4 | SUBSTITUTED ISOQUINOLINONES | PORTOLA PHARM INC (US) | 2008-08-20 | — | — | EP | disclosed |
| EP-1667989-A1 | SUBSTITUTED ISOQUINOLINONES | Portola Pharmaceuticals, Inc. (US) | 2006-06-14 | — | — | EP | disclosed |
| WO-2005035520-A1 | SUBSTITUTED ISOQUINOLINONES | PORTOLA PHARMACEUTICALS, INC. (US) | 2005-04-21 | — | — | WO | disclosed |