Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | SIRT6 | Q8N6T7 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 7/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.33 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.33 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL376853 | 0.71 | HSPB1 (0.47) | KMT2AMAPTALDH1A1LMNAMAPK1 | |
| SCHEMBL4649319 | 0.71 | ALDH1A1 (0.44) | MEN1KMT2AMAPTALDH1A1LMNA | |
| SCHEMBL4646264 | 0.71 | ESR2 (0.36) | POLBMEN1KMT2AMAPTHSPB1 | |
| SCHEMBL4648651 | 0.71 | MAPT (0.44) | POLBMEN1KMT2ASIRT6MAPT | |
| SCHEMBL16858557 | 0.67 | KCNN4 (0.38) | POLBMEN1KMT2AALDH1A1GAA | |
| SCHEMBL8616810 | 0.67 | HSPB1 (0.51) | POLBMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL37687 | 0.65 | CA1 (0.62) | MEN1KMT2AMAPTALDH1A1LMNA | |
| SCHEMBL10035008 | 0.65 | ALDH1A1 (0.50) | MEN1KMT2AMAPTALDH1A1LMNA | |
| SCHEMBL2589545 | 0.65 | MAPK1 (0.36) | MAPTALDH1A1LMNAMAPK1GAA | |
| SCHEMBL14511816 | 0.64 | PDGFRB (0.42) | MEN1KMT2AALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1667989-A4 | SUBSTITUTED ISOQUINOLINONES | PORTOLA PHARM INC (US) | 2008-08-20 | — | — | EP | disclosed |
| EP-1667989-A1 | SUBSTITUTED ISOQUINOLINONES | Portola Pharmaceuticals, Inc. (US) | 2006-06-14 | — | — | EP | disclosed |
| WO-2005035520-A1 | SUBSTITUTED ISOQUINOLINONES | PORTOLA PHARMACEUTICALS, INC. (US) | 2005-04-21 | — | — | WO | disclosed |