Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 8/20 | 0.40 |
| ▸ | TSHR | P16473 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 4/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6403396 | 0.94 | GAA (0.44) | ALDH1A1GAATSHRLMNAUSP2 | |
| SCHEMBL4649545 | 0.93 | GAA (0.38) | ALDH1A1GAATSHRLMNAUSP2 | |
| SCHEMBL6406891 | 0.90 | ALDH1A1 (0.47) | ALDH1A1GAATSHRLMNAUSP2 | |
| SCHEMBL4646870 | 0.86 | GAA (0.46) | ALDH1A1GAATSHRLMNAUSP2 | |
| SCHEMBL6404449 | 0.82 | GAA (0.54) | ALDH1A1GAATSHRLMNAUSP2 | |
| SCHEMBL6409604 | 0.81 | ALDH1A1 (0.49) | ALDH1A1GAATSHRLMNAUSP2 | |
| SCHEMBL4648983 | 0.81 | ALDH1A1 (0.53) | ALDH1A1GAATSHRLMNAUSP2 | |
| SCHEMBL6409849 | 0.76 | GAA (0.52) | ALDH1A1GAATSHRLMNAUSP2 | |
| SCHEMBL6404869 | 0.74 | GAA (0.56) | ALDH1A1GAATSHRLMNAHTT | |
| SCHEMBL4686505 | 0.74 | GAA (0.53) | ALDH1A1GAATSHRLMNAUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1675834-A4 | COMPOUNDS, COMPOSITIONS, AND METHODS | CYTOKINETICS INC (US) | 2008-08-27 | — | — | EP | disclosed |
| EP-1675834-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS | Cytokinetics, Inc. (US) | 2006-07-05 | — | — | EP | disclosed |
| WO-2005037799-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS | CYTOKINETICS, INC. (US) | 2005-04-28 | — | — | WO | disclosed |