Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KHK | P50053 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | CCR4 | P51679 | 1/20 | 0.44 |
| ▸ | CCR2 | P41597 | 3/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | DPP4 | P27487 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1778652 | 0.91 | KMT2A (0.52) | KMT2ACCR2KCNH2GFERNOTUM | |
| SCHEMBL1779767 | 0.91 | KHK (0.54) | KHKKMT2ACCR4CCR2KCNH2 | |
| SCHEMBL1777518 | 0.91 | KMT2A (0.52) | KMT2ACCR2KCNH2GFERNOTUM | |
| SCHEMBL1779768 | 0.91 | KHK (0.54) | KHKKMT2ACCR4CCR2KCNH2 | |
| SCHEMBL1779017 | 0.78 | L3MBTL1 (0.56) | KMT2ACCR2KCNH2GFERNOTUM | |
| SCHEMBL1778633 | 0.77 | CCR2 (0.69) | KMT2ACCR2KCNH2NOTUMMAPT | |
| SCHEMBL1779516 | 0.77 | KMT2A (0.53) | KMT2AGFERNOTUMMAPTSMN1; SMN2 | |
| SCHEMBL1778164 | 0.76 | CCR2 (0.64) | CCR2KCNH2NOTUMMAPTSMN1; SMN2 | |
| SCHEMBL1777773 | 0.75 | CCR2 (0.63) | CCR2KCNH2NOTUMMAPTSMN1; SMN2 | |
| SCHEMBL24324251 | 0.74 | MAPT (0.55) | KHKKMT2AMAPTSMN1; SMN2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1966187-A1 | PIPERAZINE COMPOUNDS USEFUL AS ANTAGONISTS OF C-C CHEMOKINES (CCR2B AND CCR5) FOR THE TREATMENT OF INFLAMMATORY DISEASES | AstraZeneca AB (SE) | 2008-09-10 | — | — | EP | disclosed |
| WO-2007071952-A1 | PIPERAZINE COMPOUNDS USEFUL AS ANTAGONISTS OF C-C CHEMOKINES (CCR2B AND CCR5) FOR THE TREATMENT OF INFLAMMATORY DISEASES | ASTRAZENECA AB (SE) | 2007-06-28 | — | — | WO | disclosed |