Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.40 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 4/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3378373 | 0.83 | HRH3 (0.53) | HRH3MEN1KMT2AKCNH2MCHR1 | |
| SCHEMBL3376165 | 0.83 | CACNA1I (0.52) | KMT2AALDH1A1CACNA1IKCNH2MCHR1 | |
| SCHEMBL4649043 | 0.80 | HRH3 (0.50) | HRH3MEN1KMT2AKCNH2MCHR1 | |
| SCHEMBL3376675 | 0.79 | HRH3 (0.51) | HRH3MEN1KMT2AALDH1A1KCNH2 | |
| SCHEMBL3377240 | 0.77 | HRH3 (0.51) | HRH3MEN1KMT2AKCNH2MCHR1 | |
| SCHEMBL3378855 | 0.77 | HRH3 (0.48) | HRH3MEN1KMT2AKCNH2MCHR1 | |
| SCHEMBL3378858 | 0.77 | HRH3 (0.48) | HRH3MEN1KMT2AKCNH2MCHR1 | |
| SCHEMBL3376794 | 0.77 | ADRB2 (0.48) | HRH3MEN1KMT2ACACNA1IKCNH2 | |
| SCHEMBL3377637 | 0.76 | MEN1 (0.45) | HRH3MEN1KMT2AALDH1A1KCNH2 | |
| SCHEMBL3377442 | 0.76 | ADRB2 (0.49) | HRH3MEN1KMT2AKCNH2MCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899296-A1 | HISTAMINE-3 RECEPTOR ANTAGONISTS | Pfizer Products Incorporated (US) | 2008-03-19 | — | — | EP | claimed |
| WO-2006136924-A1 | HISTAMINE-3 RECEPTOR ANTAGONISTS | PFIZER PRODUCTS INC. (US) | 2006-12-28 | — | — | WO | claimed |