Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | CASP7 | P55210 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | DAO | P14920 | 3/20 | 0.31 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.31 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.31 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4649373 | 0.87 | NOTUM (0.42) | KMT2ATDP1MEN1POLBEPHX2 | |
| SCHEMBL4649821 | 0.85 | ALDH1A1 (0.34) | EPHX2ALDH1A1DAOHCRTR1BAZ2B | |
| SCHEMBL4649101 | 0.81 | GRIN2D (0.35) | EPHX2ALDH1A1DAOHCRTR1BAZ2B | |
| SCHEMBL4648846 | 0.72 | NOTUM (0.44) | TDP1EPHX2ALDH1A1DAOBAZ2B | |
| SCHEMBL27748064 | 0.70 | CYP4F2 (0.43) | KMT2AMEN1POLBHSD17B10ALDH1A1 | |
| SCHEMBL6207336 | 0.69 | NOTUM (0.48) | KMT2ATDP1EPHX2ALDH1A1 | |
| SCHEMBL22623624 | 0.68 | CA12 (0.47) | KMT2AMEN1POLBHSD17B10ALDH1A1 | |
| SCHEMBL27704327 | 0.68 | TPMT (0.38) | KMT2ATDP1MEN1POLBTSHR | |
| SCHEMBL8061456 | 0.67 | PLK1 (0.40) | POLBTSHRALDH1A1L3MBTL1SMN1; SMN2 | |
| SCHEMBL6209517 | 0.66 | NOTUM (0.53) | KMT2ATDP1MEN1POLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1960367-A2 | SUBSTITUTED PYRAZOLE COMPOUNDS USEFUL AS SOLUBLE EPOXIDE HYDROLASE INHIBITORS | Boehringer Ingelheim International GmbH (DE) | 2008-08-27 | — | — | EP | disclosed |
| WO-2007067836-A2 | SUBSTITUTED PYRAZOLE COMPOUNDS USEFUL AS SOLUBLE EPOXIDE HYDROLASE INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-06-14 | — | — | WO | disclosed |