Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 11/20 | 0.46 |
| ▸ | AKT1 | P31749 | 1/20 | 0.34 |
| ▸ | ULK1 | O75385 | 1/20 | 0.30 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.30 |
| ▸ | TDP2 | O95551 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | MMP12 | P39900 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4891714 | 0.74 | KIF11 (0.49) | KIF11NPC1MAPTMMP12RAB9A | |
| SCHEMBL4596463 | 0.74 | KIF11 (0.59) | KIF11PTGS2MAPT | |
| SCHEMBL4596019 | 0.72 | KIF11 (0.44) | KIF11AKT1PTGS2MAPT | |
| SCHEMBL4890586 | 0.72 | KIF11 (0.58) | KIF11NPC1MAPTMMP12RAB9A | |
| SCHEMBL3310186 | 0.72 | KIF11 (0.70) | KIF11ULK1NPC1MAPTMMP12 | |
| SCHEMBL4898372 | 0.71 | KIF11 (0.72) | KIF11AKT1TDP2GRIA1 | |
| SCHEMBL4888035 | 0.71 | KIF11 (0.86) | KIF11AKT1TDP2MAPT | |
| SCHEMBL4888861 | 0.69 | KIF11 (0.86) | KIF11AKT1TDP2 | |
| SCHEMBL4899671 | 0.69 | KIF11 (0.62) | KIF11NPC1MAPTMMP12RAB9A | |
| SCHEMBL1396616 | 0.68 | KIF11 (1.00) | KIF11AKT1TDP2NPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1874753-A2 | COMPOUNDS, COMPOSITIONS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-01-09 | — | — | EP | claimed |
| WO-2006113432-A2 | COMPOUNDS, COMPOSITIONS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-10-26 | — | — | WO | claimed |