SCHEMBL4649995

SCHEMBL4649995

CCCCCCCCCCCc1[c]c2c(cc1)-c1ccccc1C2

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GPR3 P46089 1/20 0.37
CYP2D6 P10635 2/20 0.36
ALDH1A1 P00352 2/20 0.36
CYP1A2 P05177 1/20 0.36
CYP2C19 P33261 1/20 0.36
PTPN1 P18031 1/20 0.35
DRD2 P14416 1/20 0.35
SLC6A2 P23975 1/20 0.35
HTR2A P28223 1/20 0.35
HTR2C P28335 1/20 0.35
SLC6A4 P31645 1/20 0.35
NPC1 O15118 2/20 0.35
RAB9A P51151 2/20 0.35
SIGMAR1 Q99720 3/20 0.34
NR1H2 P55055 1/20 0.34
NR1H3 Q13133 1/20 0.34
LMNA P02545 2/20 0.34
GAA P10253 1/20 0.34
CNR1 P21554 2/20 0.33
LIPG Q9Y5X9 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2972878 1.00 GPR3 (0.37) GPR3CYP2D6ALDH1A1CYP1A2CYP2C19
SCHEMBL216254 1.00 GPR3 (0.37) GPR3CYP2D6ALDH1A1CYP1A2CYP2C19
SCHEMBL216547 1.00 GPR3 (0.37) GPR3CYP2D6ALDH1A1CYP1A2CYP2C19
SCHEMBL218347 1.00 GPR3 (0.37) GPR3CYP2D6ALDH1A1CYP1A2CYP2C19
SCHEMBL215259 1.00 GPR3 (0.37) GPR3CYP2D6ALDH1A1CYP1A2CYP2C19
SCHEMBL215849 1.00 GPR3 (0.37) GPR3CYP2D6ALDH1A1CYP1A2CYP2C19
SCHEMBL216506 0.99 NPC1 (0.35) GPR3CYP2D6ALDH1A1CYP1A2CYP2C19
SCHEMBL215716 0.94 NPC1 (0.36) CYP2D6ALDH1A1CYP1A2CYP2C19SLC6A2
SCHEMBL219159 0.88 NPC1 (0.38) CYP2D6ALDH1A1CYP1A2CYP2C19SLC6A2
SCHEMBL218357 0.82 ALDH1A1 (0.37) CYP2D6ALDH1A1CYP1A2CYP2C19SLC6A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3022233-A1 CYCLOPROPYL SUBSTITUTED METALLOCENE CATALYSTS ExxonMobil Chemical Patents Inc. (US) 2016-05-25 EP disclosed
WO-2015009473-A1 CYCLOPROPYL SUBSTITUTED METALLOCENE CATALYSTS EXXONMOBIL CHEMICAL PATENTS INC. (US) 2015-01-22 WO disclosed
EP-1963347-A1 HALOGEN SUBSTITUTED METALLOCENE COMPOUNDS FOR OLEFIN POLYMERIZATION ExxonMobil Chemical Patents, Inc., A Corporation of the State of Delaware (US) 2008-09-03 EP disclosed
EP-1960442-A1 HALOGEN SUBSTITUTED HETEROATOM-CONTAINING METALLOCENE COMPOUNDS FOR OLEFIN POLYMERIZATION ExxonMobil Chemical Patents Inc. (US) 2008-08-27 EP disclosed
EP-1866322-A2 PROCESS FOR PRODUCING SUBSTITUTED METALLOCENE COMPOUNDS FOR OLEFIN POLYMERIZATION ExxonMobil Chemical Patents Inc. (US) 2007-12-19 EP disclosed
WO-2007070046-A1 HALOGEN SUBSTITUTED HETEROATOM-CONTAINING METALLOCENE COMPOUNDS FOR OLEFIN POLYMERIZATION EXXONMOBIL CHEMICAL PATENTS INC. (US) 2007-06-21 WO disclosed
WO-2007070041-A1 HALOGEN SUBSTITUTED METALLOCENE COMPOUNDS FOR OLEFIN POLYMERIZATION EXXONMOBIL CHEMICAL PATENTS INC. (US) 2007-06-21 WO disclosed
WO-2006065844-A2 PROCESS FOR PRODUCING SUBSTITUTED METALLOCENE COMPOUNDS FOR OLEFIN POLYMERIZATION EXXONMOBIL CHEMICAL PATENTS INC. (US) 2006-06-22 WO disclosed