Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Sorbitol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | TOP1 | P11387 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Mannitol SCHEMBL11015104 | 0.93 | LMNA (0.61) | LMNAL3MBTL1TDP1KDM4EPDE4A | |
| Sorbitol SCHEMBL619756 | 0.93 | LMNA (0.61) | LMNAL3MBTL1TDP1KDM4EPDE4A | |
| Mannitol SCHEMBL3909131 | 0.93 | LMNA (0.61) | LMNAL3MBTL1TDP1KDM4EPDE4A | |
| Mannitol SCHEMBL28899433 | 0.88 | LMNA (0.55) | LMNAL3MBTL1TDP1KDM4EPDE4A | |
| Sorbitol SCHEMBL27759 | 0.88 | LMNA (0.55) | LMNAL3MBTL1TDP1KDM4EPDE4A | |
| Sorbitol SCHEMBL15060035 | 0.88 | LMNA (0.55) | LMNAL3MBTL1TDP1KDM4EPDE4A | |
| Ribitol SCHEMBL3904172 | 0.87 | LMNA (0.53) | LMNAL3MBTL1TDP1KDM4EPDE4A | |
| Xylitol SCHEMBL20561020 | 0.87 | LMNA (0.53) | LMNAL3MBTL1TDP1KDM4EPDE4A | |
| Propylene Glycol SCHEMBL18285762 | 0.87 | TDP1 (0.62) | LMNATDP1USP2TSHRALDH1A1 | |
| Propylene Glycol SCHEMBL35797 | 0.87 | TDP1 (0.62) | LMNATDP1USP2TSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1790492-B1 | Infrared sensitive planographic printing plate precursor | FUJIFILM CORP (JP) | 2008-09-10 | — | — | EP | disclosed |
| EP-1790492-A1 | Infrared sensitive planographic printing plate precursor | Fujifilm Corporation (JP) | 2007-05-30 | — | — | EP | disclosed |
| US-7078687-B2 | Thin film analyzing method | FUJI PHOTO FILM CO., LTD. (JP) | 2006-07-18 | — | — | US | disclosed |
| US-20040232330-A1 | Thin film analyzing method | FUJI PHOTO FILM CO., LTD. | 2004-11-25 | — | — | US | disclosed |