Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | MMP2 | P08253 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | MMP3 | P08254 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.37 |
| ▸ | RORC | P51449 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL39013 | 0.87 | MAPT (0.60) | MAPTALDH1A1MMP2RAB9AMMP3 | |
| SCHEMBL38464 | 0.86 | GSK3B (0.50) | MAPTALDH1A1MMP2RAB9AMMP3 | |
| SCHEMBL5223976 | 0.84 | PLA2G2A (0.54) | MAPTALDH1A1MMP2RAB9ANPC1 | |
| SCHEMBL38560 | 0.82 | MAPT (0.54) | MAPTALDH1A1RAB9ANPC1RECQL | |
| SCHEMBL5225023 | 0.82 | MAPT (0.48) | MAPTALDH1A1MMP2RAB9AMMP3 | |
| SCHEMBL14227712 | 0.76 | MAPT (0.49) | MAPTALDH1A1RAB9ANPC1RECQL | |
| SCHEMBL17640942 | 0.75 | KCNH2 (0.42) | MAPTALDH1A1NPC1RORC | |
| SCHEMBL12128097 | 0.74 | KCNH2 (0.43) | MAPTALDH1A1L3MBTL1 | |
| SCHEMBL23352170 | 0.73 | PLA2G2A (0.64) | MAPTRAB9ANPC1RECQLPLA2G2A | |
| SCHEMBL19254700 | 0.73 | CYP2A6 (0.39) | MAPTALDH1A1RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011137587-A1 | CYTOKINE INHIBITORS | HUTCHISON MEDIPHARMA LIMITED (CN) | 2011-11-10 | — | — | WO | disclosed |
| WO-2009059162-A1 | CYTOKINE INHIBITORS | HUTCHISON MEDIPHARMA ENTERPRISES LIMITED (BS) | 2009-05-07 | — | — | WO | disclosed |