Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPY1R | P25929 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | NPY2R | P49146 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.46 |
| ▸ | HRH2 | P25021 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4653089 | 1.00 | NPY1R (0.47) | NPY1RHTTNPY2RHRH3HRH2 | |
| SCHEMBL4653088 | 1.00 | NPY1R (0.47) | NPY1RHTTNPY2RHRH3HRH2 | |
| SCHEMBL4609111 | 0.92 | HRH3 (0.48) | HRH3 | |
| SCHEMBL4624618 | 0.92 | HRH3 (0.48) | HRH3 | |
| SCHEMBL14538713 | 0.92 | HRH3 (0.48) | HRH3 | |
| SCHEMBL4607992 | 0.92 | HRH3 (0.48) | HRH3 | |
| SCHEMBL4624649 | 0.88 | HRH3 (0.48) | HRH3 | |
| SCHEMBL4624657 | 0.88 | HRH3 (0.48) | HRH3 | |
| SCHEMBL15908896 | 0.83 | NPY1R (0.51) | NPY1RHTTNPY2RALDH1A1POLB | |
| SCHEMBL4608914 | 0.81 | SLC6A3 (0.47) | NPY1RHTTNPY2RHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1948605-A2 | MODULATORS OF THE H3 RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | Arena Pharmaceuticals, Inc. (US) | 2008-07-30 | — | — | EP | disclosed |
| WO-2007061741-A2 | MODULATORS OF THE H3 RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2007-05-31 | — | — | WO | disclosed |