SCHEMBL4654246

SCHEMBL4654246

NCCc1ccc2nc(Oc3ccc(Oc4ccccc4)cc3)sc2c1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 2/20 0.52
NPC1 O15118 1/20 0.52
TP53 P04637 1/20 0.52
MAPT P10636 1/20 0.52
HTT P42858 1/20 0.52
RAB9A P51151 1/20 0.52
TDP1 Q9NUW8 1/20 0.49
L3MBTL1 Q9Y468 1/20 0.49
LTA4H P09960 8/20 0.47
KCNH2 Q12809 3/20 0.47
CYP3A4 P08684 2/20 0.46
CYP1A2 P05177 1/20 0.46
CYP2D6 P10635 1/20 0.46
CYP2C19 P33261 1/20 0.46
CACNA1H O95180 1/20 0.43
CACNA1B Q00975 1/20 0.43
EPHX2 P34913 1/20 0.42
GRIN1 Q05586 1/20 0.42
GRIN2B Q13224 1/20 0.42
SCN4A P35499 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4692982 0.84 LTA4H (0.64) SMN1; SMN2LTA4HKCNH2CYP3A4CYP1A2
Hydrochloric Acid SCHEMBL2170240 0.83 LTA4H (0.62) SMN1; SMN2LTA4HKCNH2CYP3A4CYP1A2
SCHEMBL4654087 0.82 SMN1; SMN2 (0.49) SMN1; SMN2NPC1TP53MAPTHTT
SCHEMBL11816742 0.79 MAPT (0.57) SMN1; SMN2NPC1TP53MAPTHTT
SCHEMBL7339194 0.78 KDM4E (0.46) SMN1; SMN2NPC1MAPTRAB9ACYP3A4
SCHEMBL2622429 0.77 SMN1; SMN2 (0.49) SMN1; SMN2NPC1TP53MAPTHTT
SCHEMBL22224242 0.75 LTA4H (0.62) SMN1; SMN2LTA4HKCNH2CYP3A4CYP1A2
SCHEMBL4512358 0.74 SMN1; SMN2 (0.52) SMN1; SMN2NPC1TP53MAPTHTT
SCHEMBL3717012 0.74 TRPM8 (0.49) SMN1; SMN2LTA4H
SCHEMBL18580309 0.74 LTA4H (0.45) SMN1; SMN2NPC1MAPTHTTRAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1996567-A2 NOVEL ACETYL-COA CARBOXYLASE (ACC) INHIBITORS AND THEIR USE IN DIABETES, OBESITY AND METABOLIC SYNDROME ABBOTT LABORATORIES (US) 2008-12-03 EP disclosed
WO-2007095601-A2 NOVEL ACETYL-COA CARBOXYLASE (ACC) INHIBITORS AND THEIR USE IN DIABETES, OBESITY AND METABOLIC SYNDROME ABBOTT LABORATORIES (US) 2007-08-23 WO disclosed