Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | FLT1 | P17948 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | BCHE | P06276 | 2/20 | 0.38 |
| ▸ | ACHE | P22303 | 2/20 | 0.38 |
| ▸ | BACE1 | P56817 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.37 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.37 |
| ▸ | PPARA | Q07869 | 1/20 | 0.37 |
| ▸ | LIPE | Q05469 | 1/20 | 0.37 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.36 |
| ▸ | IGF1R | P08069 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4655043 | 0.85 | EPHX2 (0.43) | POLBFLT1KDRSMN1; SMN2MAPT | |
| SCHEMBL4655163 | 0.82 | KMT2A (0.47) | L3MBTL1POLBSMN1; SMN2MAPTHTT | |
| SCHEMBL4655156 | 0.78 | TSHR (0.48) | POLBFLT1KDRMAPTHTT | |
| SCHEMBL10954922 | 0.71 | POLB (0.63) | L3MBTL1POLBMAPTNTRK1IGF1R | |
| SCHEMBL9375353 | 0.70 | POLB (0.46) | L3MBTL1POLBMAPTHCRTR1HCRTR2 | |
| SCHEMBL9378690 | 0.70 | POLB (0.46) | L3MBTL1POLBMAPTBACE1PPARA | |
| SCHEMBL28166523 | 0.68 | MAPT (0.63) | SMN1; SMN2PLA2G1BMAPTATG4BKDM1A | |
| SCHEMBL1242485 | 0.68 | MAPT (0.58) | SMN1; SMN2PLA2G1BMAPTATG4BKDM1A | |
| SCHEMBL10955104 | 0.67 | POLB (0.53) | L3MBTL1POLBSMN1; SMN2MAPTBACE1 | |
| SCHEMBL9381430 | 0.67 | POLB (0.43) | L3MBTL1POLBSMN1; SMN2MAPTPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1994009-A1 | 4-AMINO-1,5-SUBSTITUTED 1,5-DIHYDRO-IMIDAZOL-2-ONES | F.HOFFMANN-LA ROCHE AG (CH) | 2008-11-26 | — | — | EP | disclosed |
| WO-2007101802-A1 | 4-AMINO-1,5-SUBSTITUTED 1,5-DIHYDRO-IMIDAZOL-2-ONES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-09-13 | — | — | WO | disclosed |