Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 19/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1356858 | 0.91 | SIGMAR1 (0.64) | SIGMAR1KCNH2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL1354886 | 0.90 | SIGMAR1 (0.67) | SIGMAR1KCNH2ABL1 | |
| SCHEMBL1356500 | 0.83 | SIGMAR1 (0.68) | SIGMAR1KCNH2ABL1 | |
| SCHEMBL4654558 | 0.81 | SIGMAR1 (0.57) | SIGMAR1KCNH2 | |
| SCHEMBL1354963 | 0.79 | SIGMAR1 (0.60) | SIGMAR1KCNH2ABL1 | |
| SCHEMBL1354942 | 0.78 | SIGMAR1 (0.83) | SIGMAR1KCNH2 | |
| SCHEMBL1357533 | 0.77 | SIGMAR1 (0.85) | SIGMAR1 | |
| SCHEMBL1356799 | 0.77 | SIGMAR1 (0.85) | SIGMAR1KCNH2 | |
| SCHEMBL1356927 | 0.75 | SIGMAR1 (0.69) | SIGMAR1KCNH2ABL1 | |
| SCHEMBL4656581 | 0.75 | SIGMAR1 (0.69) | SIGMAR1ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1994008-A2 | IMIDAZOLE COMPOUNDS HAVING PHARMACEUTICAL ACTIVITY TOWARDS THE SIGMA RECEPTOR | Laboratorios del Dr. Esteve S.A. (ES) | 2008-11-26 | — | — | EP | claimed |
| WO-2007098967-A2 | IMIDAZOLE COMPOUNDS HAVING PHARMACEUTICAL ACTIVITY TOWARDS THE SIGMA RECEPTOR | LABORATORIOS DEL DR.ESTEVE, S.A. (ES) | 2007-09-07 | — | — | WO | claimed |