Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | PIM1 | P11309 | 3/20 | 0.39 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | CES1 | P23141 | 1/20 | 0.37 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.37 |
| ▸ | GALR1 | P47211 | 1/20 | 0.37 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL950279 | 0.87 | POLB (0.64) | POLBTSHRPIM1PIM2NOTUM | |
| SCHEMBL4229295 | 0.84 | PIM1 (0.38) | POLBPIM1PIM2NOTUMCES1 | |
| SCHEMBL4443465 | 0.83 | POLB (0.51) | POLBTSHRPIM1PIM2NOTUM | |
| SCHEMBL3570017 | 0.69 | TSHR (0.67) | POLBTSHRRAB9A | |
| SCHEMBL953438 | 0.69 | POLB (0.69) | POLBTSHRRAB9A | |
| SCHEMBL4599178 | 0.68 | POLB (0.46) | POLBTSHRRAB9A | |
| SCHEMBL4522111 | 0.68 | POLB (0.67) | POLBTSHRRAB9A | |
| SCHEMBL950042 | 0.68 | POLB (0.71) | POLBTSHRRAB9A | |
| SCHEMBL950407 | 0.67 | TDP2 (0.39) | POLBTSHRPIM1PIM2NOTUM | |
| SCHEMBL1839876 | 0.67 | NOTUM (0.40) | PIM1PIM2NOTUMSLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1994010-A1 | COMPOUNDS WHICH INHIBIT THE GLYCINE TRANSPORTER AND USES THEREOF | GLAXO GROUP LIMITED (GB) | 2008-11-26 | — | — | EP | disclosed |
| WO-2007104775-A1 | COMPOUNDS WHICH INHIBIT THE GLYCINE TRANSPORTER AND USES THEREOF | GLAXO GROUP LIMITED (GB) | 2007-09-20 | — | — | WO | disclosed |