Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 6/20 | 0.62 |
| ▸ | SIRT1 | Q96EB6 | 5/20 | 0.62 |
| ▸ | SIRT3 | Q9NTG7 | 2/20 | 0.62 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.60 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.60 |
| ▸ | CHEK2 | O96017 | 5/20 | 0.56 |
| ▸ | PLG | P00747 | 2/20 | 0.52 |
| ▸ | PLAU | P00749 | 2/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | PARP1 | P09874 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20001715 | 0.86 | SIRT2 (0.65) | SIRT2SIRT1SIRT3PKN1PKN2 | |
| SCHEMBL18668553 | 0.86 | SIRT2 (0.83) | SIRT2SIRT1SIRT3PKN1PKN2 | |
| SCHEMBL17275543 | 0.86 | PKN1 (0.65) | SIRT2SIRT1SIRT3PKN1PKN2 | |
| SCHEMBL30343739 | 0.84 | SIRT2 (0.83) | SIRT2SIRT1SIRT3PKN1PKN2 | |
| SCHEMBL19994487 | 0.84 | SIRT2 (0.83) | SIRT2SIRT1SIRT3PKN1PKN2 | |
| SCHEMBL7333347 | 0.83 | SMN1; SMN2 (0.54) | CHEK2PLGPLAUHDAC6MAPT | |
| SCHEMBL16329639 | 0.81 | CHEK2 (0.65) | CHEK2PLGPLAUHDAC6MAPT | |
| SCHEMBL13305839 | 0.81 | PLG (0.60) | CHEK2PLGPLAUHDAC6 | |
| SCHEMBL7334119 | 0.81 | RARB (0.62) | CHEK2PLGPLAU | |
| SCHEMBL1663387 | 0.80 | CHEK2 (0.66) | CHEK2PLGPLAUHDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2194981-B1 | BISBENZIMIDAZOLES AS ANTIMALARIAL AGENTS | UNIV MONS HAINAUT (BE) | 2011-11-23 | — | — | EP | disclosed |
| US-20100160402-A1 | Bisbenzimidazoles as antimalarial agents | XAVIER UNIVERSITY OF LOUISIANA | 2010-06-24 | — | — | US | disclosed |
| US-20100160402-A1 | Bisbenzimidazoles as antimalarial agents | XAVIER UNIVERSITY OF LOUISIANA | 2010-06-24 | — | — | US | disclosed |
| US-20100160402-A1 | Bisbenzimidazoles as antimalarial agents | XAVIER UNIVERSITY OF LOUISIANA | 2010-06-24 | — | — | US | disclosed |
| EP-2194981-A1 | BISBENZIMIDAZOLES AS ANTIMALARIAL AGENTS | Université de Mons-Hainaut (BE) | 2010-06-16 | — | — | EP | disclosed |
| WO-2009043902-A1 | BISBENZIMIDAZOLES AS ANTIMALARIAL AGENTS | UNIVERSITE DE MONS HAINAUT (BE) | 2009-04-09 | — | — | WO | disclosed |
| WO-2009043902-A1 | BISBENZIMIDAZOLES AS ANTIMALARIAL AGENTS | UNIVERSITE DE MONS HAINAUT (BE) | 2009-04-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100160402-A1 | Bisbenzimidazoles as antimalarial agents | NQO2, SQOR, CPS1 | SIRT2 511/4885SIRT1 1053/4885SIRT3 682/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.