Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 1/20 | 0.47 |
| ▸ | ECE1 | P42892 | 1/20 | 0.43 |
| ▸ | GPX4 | P36969 | 1/20 | 0.42 |
| ▸ | AHR | P35869 | 1/20 | 0.42 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.42 |
| ▸ | MET | P08581 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
| ▸ | ROR1 | Q01973 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4655315 | 0.93 | ECE1 (0.48) | ECE1GPX4AHRGRM4MET | |
| SCHEMBL4656242 | 0.84 | ECE1 (0.49) | ECE1GPX4METTHRBMAPT | |
| SCHEMBL4656220 | 0.82 | ECE1 (0.59) | ECE1GPX4GRM4MAPTMAOB | |
| SCHEMBL4655371 | 0.81 | MDM2 (0.42) | GRM4THRBMAPTTSHRALDH1A1 | |
| SCHEMBL4655332 | 0.80 | MAPT (0.47) | ECE1GPX4AHRGRM4MET | |
| SCHEMBL4655241 | 0.80 | NOTUM (0.49) | ECE1GPX4METMAPTMAOB | |
| SCHEMBL4655331 | 0.79 | MAOB (0.51) | ECE1GPX4GRM4METMAPT | |
| SCHEMBL4655285 | 0.79 | ECE1 (0.53) | ECE1GPX4MAPTMAOBNOTUM | |
| SCHEMBL4656319 | 0.79 | ECE1 (0.50) | ECE1GPX4AHRGRM4MET | |
| SCHEMBL4655289 | 0.77 | ECE1 (0.53) | ECE1GPX4GRM4MAPTMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1776340-B1 | N-(1H-INDOLYL)-H-INDOLE-2-CARB0XAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USE | SANOFI AVENTIS (FR) | 2008-12-03 | — | — | EP | claimed |