Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.43 |
| ▸ | CNR1 | P21554 | 2/20 | 0.43 |
| ▸ | CNR2 | P34972 | 2/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4655438 | 0.93 | SIGMAR1 (0.51) | SIGMAR1ALDH1A1MEN1KMT2AENPP2 | |
| SCHEMBL1356509 | 0.92 | ALDH1A1 (0.56) | SIGMAR1ALDH1A1ATMMEN1KMT2A | |
| SCHEMBL4655482 | 0.92 | SIGMAR1 (0.51) | SIGMAR1ALDH1A1ATMMEN1KMT2A | |
| SCHEMBL1354905 | 0.91 | ALDH1A1 (0.58) | SIGMAR1ALDH1A1ATMMEN1KMT2A | |
| SCHEMBL1356512 | 0.90 | SIGMAR1 (0.66) | SIGMAR1ALDH1A1ATMMEN1KMT2A | |
| SCHEMBL1357071 | 0.89 | SIGMAR1 (0.68) | SIGMAR1ALDH1A1ATMMEN1KMT2A | |
| SCHEMBL1356527 | 0.84 | SIGMAR1 (0.55) | SIGMAR1ALDH1A1ATMMEN1KMT2A | |
| SCHEMBL1356504 | 0.83 | SIGMAR1 (0.54) | SIGMAR1ALDH1A1ATMMEN1KMT2A | |
| SCHEMBL4655473 | 0.83 | CNR1 (0.41) | MEN1KMT2ANPC1RAB9ACNR1 | |
| SCHEMBL1356784 | 0.79 | POLB (0.50) | SIGMAR1MEN1KMT2ACNR1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1994008-A2 | IMIDAZOLE COMPOUNDS HAVING PHARMACEUTICAL ACTIVITY TOWARDS THE SIGMA RECEPTOR | Laboratorios del Dr. Esteve S.A. (ES) | 2008-11-26 | — | — | EP | disclosed |
| WO-2007098967-A2 | IMIDAZOLE COMPOUNDS HAVING PHARMACEUTICAL ACTIVITY TOWARDS THE SIGMA RECEPTOR | LABORATORIOS DEL DR.ESTEVE, S.A. (ES) | 2007-09-07 | — | — | WO | disclosed |