Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 1/20 | 0.68 |
| ▸ | PPARA | Q07869 | 1/20 | 0.68 |
| ▸ | HDAC6 | Q9UBN7 | 11/20 | 0.57 |
| ▸ | HDAC3 | O15379 | 10/20 | 0.57 |
| ▸ | HDAC4 | P56524 | 10/20 | 0.57 |
| ▸ | HDAC1 | Q13547 | 10/20 | 0.57 |
| ▸ | HDAC7 | Q8WUI4 | 10/20 | 0.57 |
| ▸ | HDAC2 | Q92769 | 10/20 | 0.57 |
| ▸ | HDAC10 | Q969S8 | 10/20 | 0.57 |
| ▸ | HDAC11 | Q96DB2 | 10/20 | 0.57 |
| ▸ | HDAC8 | Q9BY41 | 10/20 | 0.57 |
| ▸ | HDAC9 | Q9UKV0 | 10/20 | 0.57 |
| ▸ | HDAC5 | Q9UQL6 | 10/20 | 0.57 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL465650 | 0.86 | HDAC6 (0.56) | PPARGPPARAHDAC6HDAC3HDAC4 | |
| SCHEMBL465531 | 0.85 | HDAC6 (0.57) | PPARGPPARAHDAC6HDAC3HDAC4 | |
| SCHEMBL465475 | 0.84 | HDAC6 (0.75) | PPARGPPARAHDAC6HDAC3HDAC4 | |
| SCHEMBL465587 | 0.84 | HDAC6 (0.59) | PPARGPPARAHDAC6HDAC3HDAC4 | |
| SCHEMBL6124304 | 0.82 | NPC1 (0.61) | ALDH1A1MAPTKDM4ENPC1TP53 | |
| SCHEMBL465499 | 0.82 | HDAC6 (0.54) | PPARGPPARAHDAC6HDAC3HDAC4 | |
| SCHEMBL465509 | 0.82 | HDAC6 (0.53) | PPARGPPARAHDAC6HDAC3HDAC4 | |
| SCHEMBL9094859 | 0.81 | HDAC3 (0.68) | PPARGPPARAHDAC6HDAC3HDAC4 | |
| SCHEMBL21087331 | 0.81 | NPC1 (0.60) | ALDH1A1MAPTKDM4ENPC1TP53 | |
| SCHEMBL13305854 | 0.80 | HDAC6 (0.57) | PPARGPPARAHDAC6HDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2194981-B1 | BISBENZIMIDAZOLES AS ANTIMALARIAL AGENTS | UNIV MONS HAINAUT (BE) | 2011-11-23 | — | — | EP | disclosed |
| US-20100160402-A1 | Bisbenzimidazoles as antimalarial agents | XAVIER UNIVERSITY OF LOUISIANA | 2010-06-24 | — | — | US | disclosed |
| US-20100160402-A1 | Bisbenzimidazoles as antimalarial agents | XAVIER UNIVERSITY OF LOUISIANA | 2010-06-24 | — | — | US | disclosed |
| US-20100160402-A1 | Bisbenzimidazoles as antimalarial agents | XAVIER UNIVERSITY OF LOUISIANA | 2010-06-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100160402-A1 | Bisbenzimidazoles as antimalarial agents | NQO2, SQOR, CPS1 | PPARG 3603/4885PPARA 2717/4885HDAC6 758/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.