Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 9/20 | 0.53 |
| ▸ | CSF1R | P07333 | 8/20 | 0.53 |
| ▸ | KDR | P35968 | 6/20 | 0.53 |
| ▸ | FLT3 | P36888 | 5/20 | 0.53 |
| ▸ | MET | P08581 | 8/20 | 0.52 |
| ▸ | AXL | P30530 | 3/20 | 0.52 |
| ▸ | FLT4 | P35916 | 2/20 | 0.49 |
| ▸ | PDGFRA | P16234 | 4/20 | 0.46 |
| ▸ | KIT | P10721 | 2/20 | 0.46 |
| ▸ | RET | P07949 | 1/20 | 0.46 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4984789 | 0.91 | PDGFRB (0.52) | PDGFRBCSF1RKDRFLT3MET | |
| SCHEMBL2173338 | 0.79 | PDGFRB (0.70) | PDGFRBCSF1RKDRFLT3MET | |
| SCHEMBL2174773 | 0.79 | MET (0.61) | PDGFRBCSF1RKDRFLT3MET | |
| SCHEMBL2174778 | 0.79 | CSF1R (0.60) | PDGFRBCSF1RKDRFLT3MET | |
| SCHEMBL2173639 | 0.79 | MET (0.62) | PDGFRBCSF1RKDRFLT3MET | |
| SCHEMBL2174541 | 0.78 | PDGFRB (0.69) | PDGFRBCSF1RKDRFLT3MET | |
| SCHEMBL2174923 | 0.76 | CSF1R (0.59) | PDGFRBCSF1RKDRFLT3MET | |
| SCHEMBL2176647 | 0.76 | PDGFRB (0.83) | PDGFRBCSF1RKDRFLT3MET | |
| SCHEMBL2174910 | 0.73 | MET (0.53) | PDGFRBCSF1RKDRFLT3MET | |
| SCHEMBL1898525 | 0.73 | AXL (0.55) | KDRMETAXLPDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1994025-A1 | QUINOLINE DERIVATIVES | AstraZeneca AB (SE) | 2008-11-26 | — | — | EP | disclosed |
| WO-2007099326-A1 | QUINOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2007-09-07 | — | — | WO | disclosed |