Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.36 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | KDM6B | O15054 | 1/20 | 0.33 |
| ▸ | KDM4A | O75164 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.33 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | CYP2E1 | P05181 | 2/20 | 0.33 |
| ▸ | CYP2C8 | P10632 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4656245 | 1.00 | HTT (0.38) | HTTTDP1SIRT3NCOA3POLB | |
| SCHEMBL13320901 | 0.79 | MAPT (0.44) | HTTTDP1SIRT3POLBKMT2A | |
| SCHEMBL3284891 | 0.79 | TDP1 (0.50) | HTTTDP1SIRT3KMT2AALDH1A1 | |
| SCHEMBL17881866 | 0.79 | HTT (0.40) | HTTTDP1NCOA3KMT2AALDH1A1 | |
| SCHEMBL2848389 | 0.73 | KDM4C (0.53) | HTTTDP1KMT2AALDH1A1KDM4E | |
| SCHEMBL29952392 | 0.73 | KDM4C (0.53) | HTTTDP1KMT2AALDH1A1KDM4E | |
| SCHEMBL17257154 | 0.72 | HTT (0.35) | HTTNCOA3KMT2AALDH1A1KDM4E | |
| SCHEMBL17257156 | 0.72 | HTT (0.35) | HTTNCOA3KMT2AALDH1A1KDM4E | |
| SCHEMBL17256801 | 0.72 | KDM4E (0.35) | HTTTDP1SIRT3KMT2AALDH1A1 | |
| SCHEMBL17256799 | 0.72 | KDM4E (0.35) | HTTTDP1SIRT3KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1999110-A2 | PROCESS FOR PREPARING l-HALO-2,7-NAPHTHYRIDINYL DERIVATIVES | UCB Pharma, S.A. (BE) | 2008-12-10 | — | — | EP | disclosed |
| WO-2007107345-A2 | PROCESS FOR PREPARING l-HALO-2,7-NAPHTHYRIDINYL DERIVATIVES | UCB PHARMA, S.A. (BE) | 2007-09-27 | — | — | WO | disclosed |