Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.66 |
| ▸ | TAS2R14 | Q9NYV8 | 5/20 | 0.64 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | THRB | P10828 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | MMP3 | P08254 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17137126 | 0.90 | ALDH1A1 (0.54) | ALDH1A1TAS2R14MAPTTHRBLMNA | |
| SCHEMBL16858484 | 0.90 | TAS2R14 (0.64) | ALDH1A1TAS2R14MAPTTHRBGAA | |
| SCHEMBL4655727 | 0.89 | ALDH1A1 (0.65) | ALDH1A1TAS2R14MAPTTHRBLMNA | |
| SCHEMBL4656559 | 0.87 | ALDH1A1 (0.86) | ALDH1A1TAS2R14MAPTTHRBLMNA | |
| SCHEMBL21315083 | 0.81 | TAS2R14 (0.56) | TAS2R14KEAP1 | |
| SCHEMBL18553938 | 0.80 | ALDH1A1 (0.53) | ALDH1A1TAS2R14MAPTTHRBLMNA | |
| SCHEMBL16858409 | 0.80 | TAS2R14 (0.60) | ALDH1A1TAS2R14MAPTTHRBLMNA | |
| SCHEMBL5191217 | 0.79 | TAS2R14 (0.71) | ALDH1A1TAS2R14MAPTTHRBTSHR | |
| SCHEMBL25225813 | 0.79 | TAS2R14 (0.59) | TAS2R14MAPTKEAP1 | |
| SCHEMBL17137230 | 0.78 | ALDH1A1 (0.71) | ALDH1A1TAS2R14MAPTTHRBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1996574-A1 | QUINOLINE AND ISOQUINOLINE DERIVATIVES AS PHOSPHODIESTERASE 10 INHIBITORS | Amgen Inc. (US) | 2008-12-03 | — | — | EP | disclosed |
| US-20070299067-A1 | Quinoline and isoquinoline derivatives as phosphodiesterase 10 inhibitors | AMGEN INC. | 2007-12-27 | — | — | US | disclosed |
| WO-2007103554-A1 | QUINOLINE AND ISOQUINOLINE DERIVATIVES AS PHOSPHODIESTERASE 10 INHIBITORS | AMGEN INC. (US) | 2007-09-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070299067-A1 | Quinoline and isoquinoline derivatives as phosphodiesterase 10 inhibitors | PDE12, PDE10A, PDE4A | ALDH1A1 716/4885TAS2R14 1861/4885MAPT 3016/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.