SCHEMBL465679

SCHEMBL465679

COC(=O)c1ccccc1C(F)F

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.55
TSHR P16473 2/20 0.55
ALDH1A1 P00352 2/20 0.53
HSD17B10 Q99714 2/20 0.53
CFTR P13569 1/20 0.53
KDM4E B2RXH2 3/20 0.52
POLB P06746 2/20 0.52
ATM Q13315 2/20 0.52
KMT2A Q03164 2/20 0.51
SLC6A3 Q01959 3/20 0.49
SLC6A4 P31645 2/20 0.49
GLA P06280 1/20 0.49
CA1 P00915 1/20 0.47
CA2 P00918 1/20 0.47
CA5A P35218 1/20 0.47
CA9 Q16790 1/20 0.47
MAPT P10636 1/20 0.47
ALOX15 P16050 1/20 0.47
GAA P10253 2/20 0.46
MYC P01106 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29841597 0.85 LMNA (0.47) LMNATSHRALDH1A1HSD17B10CFTR
SCHEMBL19611955 0.85 LMNA (0.47) LMNATSHRALDH1A1HSD17B10CFTR
SCHEMBL254882 0.84 TSHR (0.59) LMNATSHRALDH1A1HSD17B10CFTR
SCHEMBL31413100 0.84 TSHR (0.46) LMNATSHRALDH1A1HSD17B10CFTR
SCHEMBL996468 0.82 TSHR (0.57) LMNATSHRALDH1A1HSD17B10CFTR
Hydrogen Peroxide SCHEMBL28473316 0.82 TSHR (0.57) LMNATSHRALDH1A1HSD17B10CFTR
SCHEMBL19612032 0.82 KDM4E (0.42) LMNATSHRALDH1A1HSD17B10CFTR
SCHEMBL13318154 0.81 LMNA (0.52) LMNATSHRALDH1A1HSD17B10CFTR
SCHEMBL6653926 0.81 TSHR (0.55) LMNATSHRALDH1A1HSD17B10CFTR
SCHEMBL16843152 0.81 KDM4E (0.60) LMNATSHRALDH1A1HSD17B10CFTR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 82 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023097386-A1 SELECTIVE HDAC6-INHIBITING N-ACYLHYDRAZONE COMPOUNDS, METHODS FOR PRODUCING SAME, COMPOSITIONS, USES, TREATMENT METHODS AND KITS EUROFARMA LABORATÓRIOS S.A (BR) 2023-06-08 WO disclosed
WO-2022180080-A1 ANTI-PROLIFERATIVE AGENTS FIRST HEALTH PHARMACEUTICALS B.V. (NL) 2022-09-01 WO disclosed
EP-4050002-A1 ANTI-PROLIFERATIVE AGENTS First Health Pharmaceuticals B.V. (NL) 2022-08-31 EP disclosed
CN-110655539-B Method for synthesizing cis-difluoromethylcyclohexane derivatives and heterocyclic compounds by hydrogenation 四川大学 2021-11-12 CN disclosed
EP-2280983-B9 C-ARYL GLYCOSIDE COMPOUNDS FOR THE TREATMENT OF DIABETES AND OBESITY TFCHEM (FR) 2021-06-09 EP disclosed
EP-2280983-B9 C-ARYL GLYCOSIDE COMPOUNDS FOR THE TREATMENT OF DIABETES AND OBESITY TFCHEM (FR) 2021-06-09 EP disclosed
EP-3267996-B1 PYRAZOLOPYRIMIDINE INHIBITORS OF IRAK4 ACTIVITY MERCK SHARP & DOHME (US) 2020-11-11 EP disclosed
EP-3268003-B1 THIENOPYRAZINE INHIBITORS OF IRAK4 ACTIVITY MERCK SHARP & DOHME (US) 2020-07-29 EP disclosed
WO-2020021024-A1 SUBSTITUTED BICYCLIC COMPOUNDS AS MODULATORS OF THE ARYL HYDROCARBON RECEPTOR (AHR) PHENEX PHARMACEUTICALS AG (DE) 2020-01-30 WO disclosed
WO-2020021024-A1 SUBSTITUTED BICYCLIC COMPOUNDS AS MODULATORS OF THE ARYL HYDROCARBON RECEPTOR (AHR) PHENEX PHARMACEUTICALS AG (DE) 2020-01-30 WO disclosed
WO-2010037129-A1 QUINAZOLINONE, QUINOLONE AND RELATED ANALOGS AS SIRTUIN MODULATORS SIRTRIS PHARMACEUTICALS INC. (US) 2010-04-01 WO disclosed
WO-2009121939-A2 C-ARYL GLYCOSIDE COMPOUNDS FOR THE TREATMENT OF DIABETES AND OBESITY TFCHEM (FR) 2009-10-08 WO disclosed
WO-2009121939-A2 C-ARYL GLYCOSIDE COMPOUNDS FOR THE TREATMENT OF DIABETES AND OBESITY TFCHEM (FR) 2009-10-08 WO disclosed
CN-101547922-A Pyrido[4,3-d]pyrimidin-4(3H)-one derivatives as calcium receptor antagonists PFIZER PRODUCT INC (US) 2009-09-30 CN disclosed
EP-2079739-A2 PYRIDO[4,3-D]PYRIMIDIN-4(3H)-ONE DERIVATIVES AS CALCIUM RECEPTOR ANTAGONISTS Pfizer Products Inc. (US) 2009-07-22 EP disclosed
US-20080085887-A1 PYRIDO [4,3-d] PYRIMIDIN-4 (3H) -ONE DERIVATIVES AS CALCIUM RECEPTOR ANTAGONISTS PFIZER INC 2008-04-10 US disclosed
US-20080085887-A1 PYRIDO [4,3-d] PYRIMIDIN-4 (3H) -ONE DERIVATIVES AS CALCIUM RECEPTOR ANTAGONISTS PFIZER INC 2008-04-10 US disclosed
US-20080085887-A1 PYRIDO [4,3-d] PYRIMIDIN-4 (3H) -ONE DERIVATIVES AS CALCIUM RECEPTOR ANTAGONISTS PFIZER INC 2008-04-10 US disclosed
WO-2008041118-A2 PYRIDO[4,3-D]PYRIMIDIN-4(3H)-ONE DERIVATIVES AS CALCIUM RECEPTOR ANTAGONISTS PFIZER PRODUCTS INC. (US) 2008-04-10 WO disclosed
WO-2008041118-A2 PYRIDO[4,3-D]PYRIMIDIN-4(3H)-ONE DERIVATIVES AS CALCIUM RECEPTOR ANTAGONISTS PFIZER PRODUCTS INC. (US) 2008-04-10 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080085887-A1 PYRIDO [4,3-d] PYRIMIDIN-4 (3H) -ONE DERIVATIVES AS CALCIUM RECEPTOR ANTAGONISTS PTH1R, VDR, P2RY1 LMNA 4665/4885TSHR 33/4885ALDH1A1 2081/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.