Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | KAT2B | Q92831 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4658079 | 0.83 | ALDH1A1 (0.41) | TSHRCYP3A4ALDH1A1HPGDMAPT | |
| SCHEMBL4656748 | 0.82 | VCAM1 (0.49) | TSHRALDH1A1HPGDMAPTNPC1 | |
| SCHEMBL16129051 | 0.81 | ALDH1A1 (0.60) | TSHRCYP3A4ALDH1A1HPGDKAT2B | |
| SCHEMBL3636229 | 0.80 | KAT2B (0.57) | TSHRCYP3A4KAT2BACHENPC1 | |
| SCHEMBL2214742 | 0.80 | ALDH1A1 (0.67) | TSHRALDH1A1HPGDMAPTACHE | |
| SCHEMBL27593715 | 0.77 | MAPT (0.48) | TSHRCYP3A4ALDH1A1HPGDMAPT | |
| SCHEMBL4658987 | 0.77 | NPC1 (0.49) | TSHRCYP3A4ALDH1A1NPC1RAB9A | |
| SCHEMBL4658092 | 0.77 | TSHR (0.49) | TSHRCYP3A4ALDH1A1KAT2BMAPT | |
| SCHEMBL4966586 | 0.76 | TSHR (0.56) | TSHRCYP3A4ALDH1A1KAT2BMAPT | |
| SCHEMBL27780345 | 0.76 | TSHR (0.56) | TSHRCYP3A4ALDH1A1KAT2BMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1295864-B1 | PROCESS FOR PREPARATION OF 1,5-DIAMINONAPHTHALENES | MITSUI CHEMICALS POLYURETHANES (JP) | 2008-12-03 | — | — | EP | disclosed |
| US-6737548-B2 | REACTING AN ORTHO-ALKYLNITROBENZENE WITH VINYL COMPOUND IN PRESENCE OF A BASE TO PRODUCE AN INTERMEDIATE, CYCLIZING THE INTERMEDIATE TO FORM 5-NITRO-1-TETRALONE COMPOUND, THEN REACTING WITH AMINE TO PRODUCE DIAMINONAPHTHALENE COMPOUNDS | MITSUI CHEMICALS, INC. (JP) | 2004-05-18 | — | — | US | disclosed |
| US-20030176722-A1 | Process for preparation of 1,5-diaminonaphthalenes | MITSUI CHEMICALS POLYURETHANES, INC. (JP) | 2003-09-18 | — | — | US | disclosed |
| EP-1295864-A1 | PROCESS FOR PREPARATION OF 1,5-DIAMINONAPHTHALENES | Mitsui Chemicals, Inc. (JP) | 2003-03-26 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030176722-A1 | Process for preparation of 1,5-diaminonaphthalenes | NOX5, NOX1, DPYD | TSHR 4208/4885CYP3A4 154/4885ALDH1A1 159/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.