Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | CTSS | P25774 | 8/20 | 0.41 |
| ▸ | CTSK | P43235 | 8/20 | 0.41 |
| ▸ | PCNA | P12004 | 1/20 | 0.40 |
| ▸ | CTSB | P07858 | 3/20 | 0.40 |
| ▸ | APP | P05067 | 2/20 | 0.39 |
| ▸ | ACE | P12821 | 1/20 | 0.38 |
| ▸ | CTSL | P07711 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4657531 | 0.89 | ATM (0.46) | ATMCTSSCTSKCTSBAPP | |
| SCHEMBL7244729 | 0.85 | ATM (0.46) | ATMCTSSCTSKPCNACTSB | |
| SCHEMBL7036935 | 0.85 | ATM (0.46) | ATMCTSSCTSKPCNACTSB | |
| SCHEMBL7244732 | 0.85 | ATM (0.46) | ATMCTSSCTSKPCNACTSB | |
| SCHEMBL7036933 | 0.85 | ATM (0.46) | ATMCTSSCTSKPCNACTSB | |
| SCHEMBL10657027 | 0.83 | ACE (0.57) | CTSSCTSKCTSBACECTSL | |
| SCHEMBL10657017 | 0.83 | ACE (0.57) | CTSSCTSKCTSBACECTSL | |
| SCHEMBL23447587 | 0.82 | KLK5 (0.52) | CTSSCTSKCTSBACECTSL | |
| SCHEMBL6479279 | 0.82 | CTSS (0.57) | ATMCTSSCTSKPCNACTSB | |
| SCHEMBL6479218 | 0.82 | CTSS (0.57) | ATMCTSSCTSKPCNACTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1006122-B1 | PHENETHYLAMINE DERIVATIVES | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2008-12-03 | — | — | EP | disclosed |
| US-6255285-B1 | GASTROINTESTINAL DISORDERS | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2001-07-03 | — | — | US | disclosed |
| EP-1006122-A1 | PHENETHYLAMINE DERIVATIVES | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2000-06-07 | — | — | EP | disclosed |