Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | DHFR | P00374 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
| ▸ | GCK | P35557 | 1/20 | 0.45 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.44 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7933437 | 0.83 | POLB (0.50) | SMN1; SMN2POLBKMT2ADHFREGFR | |
| SCHEMBL465864 | 0.82 | SIRT1 (0.54) | SMN1; SMN2BRPF1POLBKMT2ADHFR | |
| SCHEMBL6183627 | 0.79 | GAA (0.52) | SMN1; SMN2KMT2AENPP2LMNAMAPT | |
| SCHEMBL998227 | 0.79 | SMN1; SMN2 (0.45) | SMN1; SMN2BRPF1POLBKMT2ADHFR | |
| SCHEMBL12631198 | 0.79 | SMN1; SMN2 (0.60) | SMN1; SMN2ENPP2CXCR4MAPTHTT | |
| SCHEMBL20640297 | 0.79 | ACKR3 (0.47) | SMN1; SMN2BRPF1KMT2AADRA2BSLC6A4 | |
| SCHEMBL741687 | 0.78 | SMN1; SMN2 (0.58) | SMN1; SMN2ENPP2CXCR4MAPTHTT | |
| SCHEMBL20640385 | 0.78 | ACKR3 (0.47) | BRPF1ADRA2BSLC6A4SLC6A3TMEM97 | |
| SCHEMBL7426981 | 0.78 | ENPP2 (0.47) | SMN1; SMN2POLBKMT2AEGFRENPP2 | |
| SCHEMBL7426978 | 0.78 | SMN1; SMN2 (0.46) | SMN1; SMN2KMT2AGCKENPP2CXCR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013059587-A9 | SUBSTITUTED BICYCLIC AZA-HETEROCYCLES AND ANALOGUES AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC (US) | 2014-10-23 | — | — | WO | disclosed |
| EP-2344475-A1 | QUINAZOLINONE, QUINOLONE AND RELATED ANALOGS AS SIRTUIN MODULATORS | Sirtris Pharmaceuticals, Inc. (US) | 2011-07-20 | — | — | EP | disclosed |
| CN-102112475-A | Imidazopyridine and related analogs as sirtuin modulators | SIRTRIS PHARMACEUTICALS INC | 2011-06-29 | — | — | CN | disclosed |
| WO-2010037129-A1 | QUINAZOLINONE, QUINOLONE AND RELATED ANALOGS AS SIRTUIN MODULATORS | SIRTRIS PHARMACEUTICALS INC. (US) | 2010-04-01 | — | — | WO | disclosed |