Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | AURKA | O14965 | 2/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | APP | P05067 | 1/20 | 0.41 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.41 |
| ▸ | HTR3A | P46098 | 1/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
| ▸ | CDK9 | P50750 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9881006 | 0.88 | MAPK1 (0.53) | ALDH1A1AURKAAURKBMAPK1KDM4E | |
| SCHEMBL497346 | 0.82 | MAPT (0.49) | ALDH1A1AURKAAURKBHRH4KDM4E | |
| SCHEMBL497514 | 0.78 | MAPK1 (0.49) | ALDH1A1AURKAAURKBMAPK1APP | |
| SCHEMBL497205 | 0.77 | AURKA (0.43) | ALDH1A1AURKAAURKBMAPK1APP | |
| SCHEMBL4658375 | 0.76 | NR4A2 (0.42) | ALDH1A1AURKAAURKBHSP90AB1HRH4 | |
| SCHEMBL9881008 | 0.75 | ALDH1A1 (0.47) | ALDH1A1MAPK1HTR3AHRH4KDM4E | |
| SCHEMBL9881003 | 0.73 | ALDH1A1 (0.44) | ALDH1A1KDM4ESMN1; SMN2LMNARAB9A | |
| SCHEMBL11822896 | 0.72 | ALDH1A1 (0.61) | ALDH1A1AURKAAURKBMAPK1KDM4E | |
| SCHEMBL29074154 | 0.72 | MAPK1 (0.60) | ALDH1A1AURKAAURKBMAPK1KDM4E | |
| SCHEMBL497654 | 0.71 | MAPK1 (0.52) | ALDH1A1AURKAAURKBMAPK1HSP90AB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1999112-B1 | SUBSTITUTED 2-AMINO-4-PHENYL-DIHYDROQUINOLINES, METHOD FOR THE PRODUCTION THEREOF, USE THEREOF AS MEDICAMENTS, AND MEDICAMENTS CONTAINING THEM | SANOFI SA (FR) | 2015-04-22 | — | — | EP | disclosed |
| CN-101395137-A | Substituted 2-amino-4-phenyl-dhydroquinolines, method for the production thereof, use thereof as medicaments, and medicaments containing them | SANOFI AVENTIS (FR) | 2009-03-25 | — | — | CN | disclosed |
| EP-1999112-A2 | SUBSTITUTED 2-AMINO-4-PHENYL-D HYDROQUINOLINES, METHOD FOR THE PRODUCTION THEREOF, USE THEREOF AS MEDICAMENTS, AND MEDICAMENTS CONTAINING THEM | Sanofi-Aventis (FR) | 2008-12-10 | — | — | EP | disclosed |
| WO-2007107246-A2 | SUBSTITUTED 2-AMINO-4-PHENYL-DιHYDROQUINOLINES, METHOD FOR THE PRODUCTION THEREOF, USE THEREOF AS MEDICAMENTS, AND MEDICAMENTS CONTAINING THEM | SANOFI-AVENTIS (DE) | 2007-09-27 | — | — | WO | disclosed |