Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | AURKA | O14965 | 1/20 | 0.48 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.48 |
| ▸ | APP | P05067 | 2/20 | 0.46 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.46 |
| ▸ | BACE1 | P56817 | 3/20 | 0.45 |
| ▸ | ELANE | P08246 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 5/20 | 0.41 |
| ▸ | BCHE | P06276 | 4/20 | 0.41 |
| ▸ | GRIN1 | Q05586 | 4/20 | 0.41 |
| ▸ | GRIN2A | Q12879 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL497480 | 0.89 | MAPK1 (0.61) | MAPK1AURKAAURKBBACE1ELANE | |
| SCHEMBL497205 | 0.78 | AURKA (0.43) | MAPK1AURKAAURKBAPPHSP90AB1 | |
| SCHEMBL4658374 | 0.78 | ALDH1A1 (0.44) | MAPK1AURKAAURKBAPPHSP90AB1 | |
| SCHEMBL11140622 | 0.75 | GRM2 (0.45) | BACE1ACHEBCHEALDH1A1GAA | |
| SCHEMBL8410911 | 0.73 | MAPK1 (0.82) | MAPK1AURKAAURKBELANEALDH1A1 | |
| SCHEMBL3268543 | 0.73 | ACHE (0.45) | MAPK1HSP90AB1BACE1ACHEBCHE | |
| SCHEMBL3266785 | 0.73 | ACHE (0.45) | HSP90AB1BACE1ACHEBCHEGRIN1 | |
| SCHEMBL11826284 | 0.71 | MAPK1 (0.65) | MAPK1AURKAAURKBELANEALDH1A1 | |
| SCHEMBL8956330 | 0.71 | MAPK1 (0.85) | MAPK1AURKAAURKBELANEALDH1A1 | |
| SCHEMBL11826655 | 0.71 | DHODH (0.52) | MAPK1AURKAAURKBHSP90AB1ELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1999112-B1 | SUBSTITUTED 2-AMINO-4-PHENYL-DIHYDROQUINOLINES, METHOD FOR THE PRODUCTION THEREOF, USE THEREOF AS MEDICAMENTS, AND MEDICAMENTS CONTAINING THEM | SANOFI SA (FR) | 2015-04-22 | — | — | EP | disclosed |
| US-8106204-B2 | Substituted 2-amino-4-phenyldihydroquinolines, processes for their preparation, pharmaceutical compositions and methods for their use | SANOFI-AVENTIS (FR) | 2012-01-31 | — | — | US | disclosed |
| US-20090118329-A1 | Novel Substituted 2-Amino-4-Phenyldihydroquinolines, Processes for their Preparation, Pharmaceutical Compositions and Methods for Their Use | SANOFI-AVENTIS (FR) | 2009-05-07 | — | — | US | disclosed |
| CN-101395137-A | Substituted 2-amino-4-phenyl-dhydroquinolines, method for the production thereof, use thereof as medicaments, and medicaments containing them | SANOFI AVENTIS (FR) | 2009-03-25 | — | — | CN | disclosed |
| EP-1999112-A2 | SUBSTITUTED 2-AMINO-4-PHENYL-D HYDROQUINOLINES, METHOD FOR THE PRODUCTION THEREOF, USE THEREOF AS MEDICAMENTS, AND MEDICAMENTS CONTAINING THEM | Sanofi-Aventis (FR) | 2008-12-10 | — | — | EP | disclosed |
| WO-2007107246-A2 | SUBSTITUTED 2-AMINO-4-PHENYL-DιHYDROQUINOLINES, METHOD FOR THE PRODUCTION THEREOF, USE THEREOF AS MEDICAMENTS, AND MEDICAMENTS CONTAINING THEM | SANOFI-AVENTIS (DE) | 2007-09-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090118329-A1 | Novel Substituted 2-Amino-4-Phenyldihydroquinolines, Processes for their Preparation, Pharmaceutical Compositions and Methods for Their Use | NHERF1, SLC10A1, SLC9A3 | MAPK1 2418/4885AURKA 3081/4885AURKB 3165/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.